Nicolas Moitessier
Overview
Explore the profile of Nicolas Moitessier including associated specialties, affiliations and a list of published articles.
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Articles
81
Citations
795
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Recent Articles
1.
Rivera M, Ayon O, Diaconescu-Grabari S, Pottel J, Moitessier N, Mittermaier A, et al.
Nucleic Acids Res
. 2024 Feb;
52(6):3164-3179.
PMID: 38375901
The capacity of riboswitches to undergo conformational changes in response to binding their native ligands is closely tied to their functional roles and is an attractive target for antimicrobial drug...
2.
Wang G, Venegas F, Rueda A, Weerasinghe N, Uggowitzer K, Thibodeaux C, et al.
Protein Sci
. 2023 Dec;
33(1):e4857.
PMID: 38058248
The 3C-like protease (3CL ) is crucial to the replication of SARS-CoV-2, the causative agent of COVID-19, and is the target of several successful drugs including Paxlovid and Xocova. Nevertheless,...
3.
Jablonka K, Ai Q, Al-Feghali A, Badhwar S, Bocarsly J, M Bran A, et al.
Digit Discov
. 2023 Nov;
2(5):1233-1250.
PMID: 38013906
Large-language models (LLMs) such as GPT-4 caught the interest of many scientists. Recent studies suggested that these models could be useful in chemistry and materials science. To explore these possibilities,...
4.
Wang G, Moitessier N, Mittermaier A
Chem Commun (Camb)
. 2023 Aug;
59(73):10866-10882.
PMID: 37609777
Drugs that act by covalently attaching to their targets have been used to treat human diseases for over a hundred years. However, the deliberate design of covalent drugs was discouraged...
5.
Hennecker C, Yamout L, Zhang C, Zhao C, Hiraki D, Moitessier N, et al.
Int J Mol Sci
. 2022 Dec;
23(24).
PMID: 36555662
Intramolecular guanine quadruplexes (G4s) are non-canonical nucleic acid structures formed by four guanine (G)-rich tracts that assemble into a core of stacked planar tetrads. G4-forming DNA sequences are enriched in...
6.
Sharon I, Pinus S, Grogg M, Moitessier N, Hilvert D, Schmeing T
Nat Commun
. 2022 Jul;
13(1):3923.
PMID: 35798723
Cyanophycin is a nitrogen reserve biopolymer in many bacteria that has promising industrial applications. Made by cyanophycin synthetase 1 (CphA1), it has a poly-L-Asp backbone with L-Arg residues attached to...
7.
Plescia J, Hedou D, Pousse M, Labarre A, Dufresne C, Mittermaier A, et al.
Eur J Med Chem
. 2022 Jul;
240:114543.
PMID: 35797897
We have previously described several different chemical series of bicyclic prolyl oligopeptidase (POP) inhibitors as probes for neurodegenerative diseases that demonstrated nanomolar activity in vitro and submicromolar activity in cellulo....
8.
9.
Bijian K, Wernic D, Nivedha A, Su J, Lim F, Miron C, et al.
J Med Chem
. 2022 Feb;
65(4):3134-3150.
PMID: 35167283
Aurora kinases and protein kinase C (PKC) have been shown to be involved in different aspects of cancer progression. To date, no dual Aurora/PKC inhibitor with clinical efficacy and low...
10.
Labarre A, Stille J, Patrascu M, Martins A, Pottel J, Moitessier N
J Chem Inf Model
. 2022 Feb;
62(4):1061-1077.
PMID: 35133156
Over the years, structure-based design programs and specifically docking small molecules to proteins have become prominent in drug discovery. However, many of these computational tools have been developed to primarily...