Nicolas Moitessier
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Explore the profile of Nicolas Moitessier including associated specialties, affiliations and a list of published articles.
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81
Citations
795
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Recent Articles
11.
Stille J, Tjutrins J, Wang G, Venegas F, Hennecker C, Rueda A, et al.
Eur J Med Chem
. 2022 Jan;
229:114046.
PMID: 34995923
Severe diseases such as the ongoing COVID-19 pandemic, as well as the previous SARS and MERS outbreaks, are the result of coronavirus infections and have demonstrated the urgent need for...
12.
Uggowitzer K, Habibi Y, Wei W, Moitessier N, Thibodeaux C
Biochemistry
. 2021 Jan;
60(5):412-430.
PMID: 33507068
Class II lanthipeptide synthetases (LanM enzymes) catalyze the multistep post-translational modification of genetically encoded precursor peptides into macrocyclic (often antimicrobial) lanthipeptides. The reaction sequence involves dehydration of serine/threonine residues, followed...
13.
Ross J, Miron C, Plescia J, Laplante P, McBride K, Moitessier N, et al.
Eur J Med Chem
. 2021 Jan;
213:113137.
PMID: 33460833
The MYC oncogene is considered to be a high priority target for clinical intervention in cancer patients due to its aberrant activation in more than 50% of human cancers. Direct...
14.
Wang Y, Wang G, Moitessier N, Mittermaier A
Front Mol Biosci
. 2020 Nov;
7:583826.
PMID: 33195429
Isothermal titration calorimetry (ITC) involves accurately measuring the heat that is released or absorbed in real time when one solution is titrated into another. This technique is usually used to...
15.
Oliver C, Mallet V, Gendron R, Reinharz V, Hamilton W, Moitessier N, et al.
Nucleic Acids Res
. 2020 Jul;
48(14):7690-7699.
PMID: 32652015
RNA-small molecule binding is a key regulatory mechanism which can stabilize 3D structures and activate molecular functions. The discovery of RNA-targeting compounds is thus a current topic of interest for...
16.
Wei W, Champion C, Barigye S, Liu Z, Labute P, Moitessier N
J Chem Inf Model
. 2020 Jun;
60(7):3534-3545.
PMID: 32589419
Over the past few decades, virtual high-throughput screening (vHTS) and molecular dynamics simulations have become effective and widely used tools in the initial stages of drug discovery efforts. These methods...
17.
Plescia J, Moitessier N
Eur J Med Chem
. 2020 Apr;
195:112270.
PMID: 32302879
Research related to boronic acids, from synthetic development to materials to drug discovery, has skyrocketed in the past 20 years. In terms of drug discovery, the incorporation of boronic acids...
18.
Plescia J, Dufresne C, Janmamode N, Wahba A, Mittermaier A, Moitessier N
Eur J Med Chem
. 2019 Nov;
185:111783.
PMID: 31732257
Over the past decade, many drug discovery endeavors have been invested in targeting the serine proteases prolyl oligopeptidase (POP) for the treatment of Alzheimer's and Parkinson's disease and, more recently,...
19.
Champion C, Barigye S, Wei W, Liu Z, Labute P, Moitessier N
J Chem Inf Model
. 2019 Oct;
59(11):4750-4763.
PMID: 31589815
Applications of computational methods to predict binding affinities for protein/drug complexes are routinely used in structure-based drug discovery. Applications of these methods often rely on empirical force fields (FFs) and...
20.
Tomberg A, Kundu S, Zhou F, Li C, Moitessier N
ACS Omega
. 2019 Aug;
3(3):3218-3227.
PMID: 31458579
Ruthenium catalysts have been found to be of great use for many kinds of reactions. Understanding the details of the catalytic cycle allows to not only rationalize experimental results but...