Nicolas Jae
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Explore the profile of Nicolas Jae including associated specialties, affiliations and a list of published articles.
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22
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1204
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Recent Articles
1.
Aslan G, Jae N, Manavski Y, Fouani Y, Shumliakivska M, Kettenhausen L, et al.
JCI Insight
. 2023 Mar;
8(5).
PMID: 36883566
The adult mammalian heart has limited regenerative capacity, while the neonatal heart fully regenerates during the first week of life. Postnatal regeneration is mainly driven by proliferation of preexisting cardiomyocytes...
2.
de Oliveira Freitas Machado C, Schafranek M, Bruggemann M, Hernandez Canas M, Keller M, Di Liddo A, et al.
Nucleic Acids Res
. 2023 Jan;
51(2):870-890.
PMID: 36620874
Hypoxia induces massive changes in alternative splicing (AS) to adapt cells to the lack of oxygen. Here, we identify the splicing factor SRSF6 as a key factor in the AS...
3.
Kirchhof L, Fouani Y, Knau A, Aslan G, Heumuller A, Wittig I, et al.
Noncoding RNA
. 2022 Jul;
8(4).
PMID: 35893232
Besides transcription, RNA decay accounts for a large proportion of regulated gene expression and is paramount for cellular functions. Classical RNA surveillance pathways, like nonsense-mediated decay (NMD), are also implicated...
4.
Fouani Y, Kirchhof L, Stanicek L, Luxan G, Heumuller A, Knau A, et al.
EMBO Rep
. 2022 May;
23(6):e54157.
PMID: 35527520
Vascular integrity is essential for organ homeostasis to prevent edema formation and infiltration of inflammatory cells. Long non-coding RNAs (lncRNAs) are important regulators of gene expression and often expressed in...
5.
Heumuller A, Jones A, Mourao A, Klangwart M, Shi C, Wittig I, et al.
Circ Res
. 2021 Nov;
130(1):67-79.
PMID: 34789007
Background: Circular RNAs (circRNAs) are generated by back splicing of mostly mRNAs and are gaining increasing attention as a novel class of regulatory RNAs that control various cellular functions. However,...
6.
Zehendner C, Valasarajan C, Werner A, Boeckel J, Bischoff F, John D, et al.
Am J Respir Crit Care Med
. 2020 Jul;
202(10):1445-1457.
PMID: 32634060
Long noncoding RNAs (lncRNAs) are emerging as important regulators of diverse biological functions. Their role in pulmonary arterial hypertension (PAH) remains to be explored. To elucidate the role of TYKRIL...
7.
Trembinski D, Bink D, Theodorou K, Sommer J, Fischer A, van Bergen A, et al.
Nat Commun
. 2020 Apr;
11(1):2039.
PMID: 32341350
Long non-coding RNAs (lncRNAs) contribute to cardiac (patho)physiology. Aging is the major risk factor for cardiovascular disease with cardiomyocyte apoptosis as one underlying cause. Here, we report the identification of...
8.
Jae N, Dimmeler S
Circ Res
. 2020 Apr;
126(9):1127-1145.
PMID: 32324505
The advent of deep sequencing technologies led to the identification of a considerable amount of noncoding RNA transcripts, which are increasingly recognized for their functions in controlling cardiovascular diseases. MicroRNAs...
9.
Jae N, Heumuller A, Fouani Y, Dimmeler S
Vascul Pharmacol
. 2019 Mar;
114:13-22.
PMID: 30910127
The advent of deep sequencing technologies recently unraveled the complexity of the human genome: Although almost entirely transcribed, only a very minor part of our genome actually accounts for protein...
10.
Cremer S, Michalik K, Fischer A, Pfisterer L, Jae N, Winter C, et al.
Circulation
. 2018 Dec;
139(10):1320-1334.
PMID: 30586743
Background: The majority of the human genome comprises noncoding sequences, which are in part transcribed as long noncoding RNAs (lncRNAs). lncRNAs exhibit multiple functions, including the epigenetic control of gene...