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Nicolas Campolo

Explore the profile of Nicolas Campolo including associated specialties, affiliations and a list of published articles. Areas
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Articles 8
Citations 208
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Recent Articles
1.
Galeano P, de Ceglia M, Mastrogiovanni M, Campanelli L, Medina-Vera D, Campolo N, et al.
Int J Mol Sci . 2023 Dec; 24(23). PMID: 38069333
This work aims to clarify the effect of dietary polyunsaturated fatty acid (PUFA) intake on the adult brain affected by amyloid pathology. McGill-R-Thy1-APP transgenic (Tg) rat and 5xFAD Tg mouse...
2.
Kiyuna L, Candido D, Bechara L, Jesus I, Ramalho L, Krum B, et al.
Eur Heart J . 2023 Nov; 44(44):4696-4712. PMID: 37944136
Background And Aims: Developing novel therapies to battle the global public health burden of heart failure remains challenging. This study investigates the underlying mechanisms and potential treatment for 4-hydroxynonenal (4-HNE)...
3.
Campolo N, Mastrogiovanni M, Mariotti M, Issoglio F, Estrin D, Hagglund P, et al.
J Biol Chem . 2023 Jan; 299(3):102941. PMID: 36702251
Glutamine synthetase (GS), which catalyzes the ATP-dependent synthesis of L-glutamine from L-glutamate and ammonia, is a ubiquitous and conserved enzyme that plays a pivotal role in nitrogen metabolism across all...
4.
Ott C, Tomasina F, Campolo N, Bartesaghi S, Mastrogiovanni M, Leyva A, et al.
Redox Biol . 2021 Aug; 46:102106. PMID: 34455147
Removal of moderately oxidized proteins is mainly carried out by the proteasome, while highly modified proteins are no longer degradable. However, in the case of proteins modified by nitration of...
5.
Campolo N, Issoglio F, Estrin D, Bartesaghi S, Radi R
Essays Biochem . 2020 Feb; 64(1):111-133. PMID: 32016371
Oxidative post-translational modification of proteins by molecular oxygen (O2)- and nitric oxide (•NO)-derived reactive species is a usual process that occurs in mammalian tissues under both physiological and pathological conditions...
6.
Ferrer-Sueta G, Campolo N, Trujillo M, Bartesaghi S, Carballal S, Romero N, et al.
Chem Rev . 2018 Feb; 118(3):1338-1408. PMID: 29400454
Peroxynitrite is a short-lived and reactive biological oxidant formed from the diffusion-controlled reaction of the free radicals superoxide (O) and nitric oxide (NO). In this review, we first analyze the...
7.
Issoglio F, Campolo N, Zeida A, Grune T, Radi R, Estrin D, et al.
Biochemistry . 2016 Sep; 55(42):5907-5916. PMID: 27685475
Glutamine synthetase is an important enzyme that catalyzes the ATP-dependent formation of glutamine from glutamate and ammonia. In mammals, it plays a key role in preventing excitotoxicity in the brain...
8.
Campolo N, Bartesaghi S, Radi R
Redox Rep . 2014 Jul; 19(6):221-31. PMID: 24977336
Protein tyrosine nitration is an oxidative postranslational modification that can affect protein structure and function. It is mediated in vivo by the production of nitric oxide-derived reactive nitrogen species (RNS),...