Nichole E LaPointe
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Explore the profile of Nichole E LaPointe including associated specialties, affiliations and a list of published articles.
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29
Citations
977
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Recent Articles
1.
Best R, LaPointe N, Azarenko O, Miller H, Genualdi C, Chih S, et al.
Toxicol Appl Pharmacol
. 2021 Apr;
421:115534.
PMID: 33852878
Monomethyl auristatin E (MMAE) is a potent anti-cancer microtubule-targeting agent (MTA) used as a payload in three approved MMAE-containing antibody drug conjugates (ADCs) and multiple ADCs in clinical development to...
2.
Best R, LaPointe N, Liang J, Ruan K, Shade M, Wilson L, et al.
J Biol Chem
. 2019 Jul;
294(33):12265-12280.
PMID: 31266806
The microtubule (MT)-associated protein tau regulates the critical growing and shortening behaviors of MTs, and its normal activity is essential for neuronal development and maintenance. Accordingly, aberrant tau action is...
3.
de Almeida N, Do T, LaPointe N, Tro M, Feinstein S, Shea J, et al.
Int J Mass Spectrom
. 2017 Oct;
420:24-34.
PMID: 29056865
The early oligomerization of amyloid -protein (A) is a crucial step in the etiology of Alzheimer's disease (AD), in which soluble and highly neurotoxic oligomers are produced and accumulated inside...
4.
Feinstein S, LaPointe N
Methods Cell Biol
. 2017 Sep;
141:xvii-xix.
PMID: 28882314
No abstract available.
5.
Best R, Chung P, Benbow S, Savage A, LaPointe N, Safinya C, et al.
Methods Cell Biol
. 2017 Sep;
141:3-26.
PMID: 28882309
In this chapter, we describe methods for the purification of both untagged and polyhistidine-tagged tau protein. These protocols utilize a bacterial expression system to produce the tau isoform of interest,...
6.
Cook B, Proctor D, Bromberg R, LaPointe N, Feinstein S, Wilson L
Methods Cell Biol
. 2017 Sep;
141:217-228.
PMID: 28882303
The proper organization and function of the mammalian nervous system relies on neuronal processes or "neurites," extended morphological projections that include axons and dendrites. Tau is a structural microtubule-associated protein...
7.
Smiyun G, Azarenko O, Miller H, Rifkind A, LaPointe N, Wilson L, et al.
Cancer Chemother Pharmacol
. 2017 Jun;
80(1):151-164.
PMID: 28567478
Cabazitaxel is a novel taxane approved for treatment of metastatic hormone-refractory prostate cancer in patients pretreated with docetaxel. Cabazitaxel, docetaxel, and paclitaxel bind specifically to tubulin in microtubules, disrupting functions...
8.
Feinstein H, Benbow S, LaPointe N, Patel N, Ramachandran S, Do T, et al.
J Neurochem
. 2016 Mar;
137(6):939-54.
PMID: 26953146
Despite extensive structure-function analyses, the molecular mechanisms of normal and pathological tau action remain poorly understood. How does the C-terminal microtubule-binding region regulate microtubule dynamics and bundling? In what biophysical...
9.
Do T, LaPointe N, Nelson R, Krotee P, Hayden E, Ulrich B, et al.
J Am Chem Soc
. 2015 Dec;
138(2):549-57.
PMID: 26700445
In order to evaluate potential therapeutic targets for treatment of amyloidoses such as Alzheimer's disease (AD), it is essential to determine the structures of toxic amyloid oligomers. However, for the...
10.
Do T, de Almeida N, LaPointe N, Chamas A, Feinstein S, Bowers M
Anal Chem
. 2015 Dec;
88(1):868-76.
PMID: 26632663
Ion-mobility mass spectrometry is utilized to examine the metacluster formation of serine, asparagine, isoleucine, and tryptophan. These amino acids are representative of different classes of noncharged amino acids. We show...