Lester I Binder
Overview
Explore the profile of Lester I Binder including associated specialties, affiliations and a list of published articles.
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52
Citations
3913
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Recent Articles
1.
Tiernan C, Ginsberg S, Guillozet-Bongaarts A, Ward S, He B, Kanaan N, et al.
Neurobiol Aging
. 2016 May;
42:80-90.
PMID: 27143424
Conformational phosphorylation and cleavage events drive the tau protein from a soluble, monomeric state to a relatively insoluble, polymeric state that precipitates the formation of neurofibrillary tangles (NFTs) in projection...
2.
Ward S, Himmelstein D, Ren Y, Fu Y, Yu X, Roberts K, et al.
Neurobiol Dis
. 2014 Mar;
67:37-48.
PMID: 24631720
All tauopathies result in various forms of cognitive decline and neuronal loss. Although in some diseases, tau mutations appear to cause neurodegeneration, the toxic "form" of tau remains elusive. Tau...
3.
Sahara N, Ren Y, Ward S, Binder L, Suhara T, Higuchi M
J Alzheimers Dis
. 2014 Mar;
40 Suppl 1:S91-6.
PMID: 24595194
The discovery of tau mutations in frontotemporal dementia has been a key event in neurodegenerative disease research. The rTg4510 mouse line expressing human tau with P301L FTDP-17-tau mutation has been...
4.
Jarero-Basulto J, Luna-Munoz J, Mena R, Kristofikova Z, Ripova D, Perry G, et al.
J Neuropathol Exp Neurol
. 2013 Nov;
72(12):1145-61.
PMID: 24226268
Truncated tau protein at Asp(421) is associated with neurofibrillary pathology in Alzheimer disease (AD); however, little is known about its presence in the form of nonfibrillary aggregates. Here, we report...
5.
Ward S, Himmelstein D, Lancia J, Fu Y, Patterson K, Binder L
J Alzheimers Dis
. 2013 Aug;
37(3):593-602.
PMID: 23979027
The work presented herein addresses a specific portion of the tau pathology, pre-fibrillar oligomers, now thought to be important pathological components in Alzheimer's disease and other neurodegenerative tauopathies. In previous...
6.
Monroy-Ramirez H, Basurto-Islas G, Mena R, Cisneros B, Binder L, Avila J, et al.
J Alzheimers Dis
. 2013 May;
36(3):503-20.
PMID: 23635409
Abnormal intracellular aggregation of tau protein is a pathological condition leading to neuronal death in Alzheimer's disease. Fibrillar and nonfibrillar aggregates of tau protein alter the normal functioning of neurons...
7.
Ward S, Himmelstein D, Lancia J, Binder L
Biochem Soc Trans
. 2012 Jul;
40(4):667-71.
PMID: 22817713
AD (Alzheimer's disease) is a progressive neurodegenerative disorder characterized by the extracellular accumulation of amyloid β-peptide and the intracellular accumulation of tau. Although there is much evidence linking tau to...
8.
Himmelstein D, Ward S, Lancia J, Patterson K, Binder L
Pharmacol Ther
. 2012 Jul;
136(1):8-22.
PMID: 22790092
Tau is a microtubule-associated protein thought to help modulate the stability of neuronal microtubules. In tauopathies, including Alzheimer's disease and several frontotemporal dementias, tau is abnormally modified and misfolded resulting...
9.
Kanaan N, Pigino G, Brady S, Lazarov O, Binder L, Morfini G
Exp Neurol
. 2012 Jun;
246:44-53.
PMID: 22721767
Alzheimer's disease (AD) is characterized by progressive, age-dependent degeneration of neurons in the central nervous system. A large body of evidence indicates that neurons affected in AD follow a dying-back...
10.
Voss K, Combs B, Patterson K, Binder L, Gamblin T
Biochemistry
. 2012 Jan;
51(4):888-98.
PMID: 22236337
Tauopathies are characterized by abnormal aggregation of the microtubule associated protein tau. This aggregation is thought to occur when tau undergoes shifts from its native conformation to one that exposes...