Nicholas Wheeler
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Explore the profile of Nicholas Wheeler including associated specialties, affiliations and a list of published articles.
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11
Citations
341
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Recent Articles
1.
Gorski M, Grunin M, Herold J, Frohlich B, Behr M, Wheeler N, et al.
medRxiv
. 2024 Nov;
PMID: 39606372
Age-related macular degeneration (AMD) is a leading cause of blindness with $344 billion dollars global costs. In 2016, the International Age-related Macular Degeneration Genomics Consortium devised genomic data on ∼50,000...
2.
Leung Y, Naj A, Chou Y, Valladares O, Schmidt M, Hamilton-Nelson K, et al.
Nat Commun
. 2024 Jan;
15(1):684.
PMID: 38263370
The heterogeneity of the whole-exome sequencing (WES) data generation methods present a challenge to a joint analysis. Here we present a bioinformatics strategy for joint-calling 20,504 WES samples collected across...
3.
Greenfest-Allen E, Valladares O, Kuksa P, Gangadharan P, Lee W, Cifello J, et al.
Alzheimers Dement
. 2023 Oct;
20(2):1123-1136.
PMID: 37881831
Introduction: The National Institute on Aging Genetics of Alzheimer's Disease Data Storage Site Alzheimer's Genomics Database (GenomicsDB) is a public knowledge base of Alzheimer's disease (AD) genetic datasets and genomic...
4.
Tousif S, Singh A, Umbarkar P, Galindo C, Wheeler N, Toro Cora A, et al.
Circ Res
. 2023 Jan;
132(3):267-289.
PMID: 36625265
Background: The tyrosine kinase inhibitor ponatinib is the only treatment option for chronic myelogenous leukemia patients with T315I (gatekeeper) mutation. Pharmacovigilance analysis of Food and Drug Administration and World Health...
5.
Jin B, Capra J, Benchek P, Wheeler N, Naj A, Hamilton-Nelson K, et al.
Genome Res
. 2022 Feb;
32(4):778-790.
PMID: 35210353
More than 90% of genetic variants are rare in most modern sequencing studies, such as the Alzheimer's Disease Sequencing Project (ADSP) whole-exome sequencing (WES) data. Furthermore, 54% of the rare...
6.
Bush W, Wheeler N, Darabos C, Beaulieu-Jones B
Pac Symp Biocomput
. 2021 Dec;
27:412-416.
PMID: 34890169
The majority of publications in computational biology and biocomputing develop or apply software approaches to relevant biological problems to some degree. While journals and conferences often prompt authors to make...
7.
Kumar V, Singh A, Wheeler N, Galindo C, Kim J
Expert Opin Drug Saf
. 2021 Jul;
20(11):1443-1450.
PMID: 34259127
Background: D-penicillamine (D-pen) is a copper-chelating drug and has immune-modulatory properties. D-pen is used to treat rheumatoid arthritis, Wilson's disease, and kidney stones (cystinuria). However, associated adverse events (AEs) of...
8.
Bush W, Wheeler N, Beaulieu-Jones B, Darabos C
Pac Symp Biocomput
. 2019 Dec;
25:739-742.
PMID: 31797644
The majority of accepted papers in computational biology and biocomputing describe new software approaches to relevant biological problems. While journals and conferences often require the availability of software and source...
9.
Neale D, Wegrzyn J, Stevens K, Zimin A, Puiu D, Crepeau M, et al.
Genome Biol
. 2014 Mar;
15(3):R59.
PMID: 24647006
Background: The size and complexity of conifer genomes has, until now, prevented full genome sequencing and assembly. The large research community and economic importance of loblolly pine, Pinus taeda L.,...
10.
Barakat A, Staton M, Cheng C, Park J, Yassin N, Ficklin S, et al.
BMC Plant Biol
. 2012 Mar;
12:38.
PMID: 22429310
Background: A century ago, Chestnut Blight Disease (CBD) devastated the American chestnut. Backcross breeding has been underway to introgress resistance from Chinese chestnut into surviving American chestnut genotypes. Development of...