Gerard D Schellenberg
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Explore the profile of Gerard D Schellenberg including associated specialties, affiliations and a list of published articles.
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269
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26205
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Recent Articles
1.
Wang H, Chang T, Dombroski B, Cheng P, Si Y, Tucci A, et al.
Mov Disord
. 2025 Mar;
PMID: 40055946
Background: The 17q21.31 region with various structural forms characterized by the H1/H2 haplotypes and three large copy number variations (CNVs) represents the strongest risk locus in progressive supranuclear palsy (PSP)....
2.
Kang M, Ang T, Devine S, Sherva R, Mukherjee S, Trittschuh E, et al.
medRxiv
. 2025 Feb;
PMID: 39990565
Background: Genome-wide association studies (GWAS) have identified over 1,000 blood pressure (BP) loci and over 80 loci for Alzheimer's disease (AD). Considering BP is an AD risk factor, identifying pleiotropy...
3.
Guo M, Lee W, Vardarajan B, Schellenberg G, Phillips-Cremins J
Nat Commun
. 2025 Jan;
16(1):1126.
PMID: 39875385
Studies of the genetics of Alzheimer's disease (AD) have largely focused on single nucleotide variants and short insertions/deletions. However, most of the disease heritability has yet to be uncovered, suggesting...
4.
Leung Y, Lee W, Kuzma A, Nicaretta H, Valladares O, Gangadharan P, et al.
medRxiv
. 2024 Dec;
PMID: 39677464
The Alzheimer's Disease Sequencing Project (ADSP) is a national initiative to understand the genetic architecture of Alzheimer's Disease and Related Dementias (AD/ADRD) by sequencing whole genomes of affected participants and...
5.
Le Borgne J, Gomez L, Heikkinen S, Amin N, Ahmad S, Choi S, et al.
Mol Psychiatry
. 2024 Dec;
PMID: 39633006
Due to methodological reasons, the X-chromosome has not been featured in the major genome-wide association studies on Alzheimer's Disease (AD). To address this and better characterize the genetic landscape of...
6.
Tong T, Zhu C, Farrell J, Khurshid Z, Martin E, Pericak-Vance M, et al.
Alzheimers Res Ther
. 2024 Oct;
16(1):234.
PMID: 39444005
Background: Blood-derived mitochondrial DNA copy number (mtDNA-CN) is a proxy measurement of mitochondrial function in the peripheral and central systems. Abnormal mtDNA-CN not only indicates impaired mtDNA replication and transcription...
7.
Lee W, Choi S, Shea M, Cheng P, Dombroski B, Pitsillides A, et al.
Alzheimers Dement
. 2024 Oct;
20(12):8470-8483.
PMID: 39428839
Introduction: Alzheimer's disease (AD) is a common disorder of the elderly that is both highly heritable and genetically heterogeneous. Methods: We investigated the association of AD with both common variants...
8.
Wang H, Chang T, Dombroski B, Cheng P, Patil V, Valiente-Banuet L, et al.
Mol Neurodegener
. 2024 Oct;
19(1):73.
PMID: 39402686
No abstract available.
9.
Shade L, Katsumata Y, Abner E, Aung K, Claas S, Qiao Q, et al.
Nat Genet
. 2024 Oct;
56(11):2407-2421.
PMID: 39379761
Genome-wide association studies (GWAS) have identified >80 Alzheimer's disease and related dementias (ADRD)-associated genetic loci. However, the clinical outcomes used in most previous studies belie the complex nature of underlying...
10.
Burton E, Argenziano M, Cook K, Ridler M, Lu S, Su C, et al.
bioRxiv
. 2024 Sep;
PMID: 39229212
Late-onset Alzheimer's disease (LOAD) research has principally focused on neurons over the years due to their known role in the production of amyloid beta plaques and neurofibrillary tangles. In contrast,...