Nicholas N Nickerson
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Explore the profile of Nicholas N Nickerson including associated specialties, affiliations and a list of published articles.
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19
Citations
481
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Recent Articles
1.
Diao J, Komura R, Sano T, Pantua H, Storek K, Inaba H, et al.
J Bacteriol
. 2021 Apr;
203(13):e0014921.
PMID: 33875545
Lipoprotein diacylglyceryl transferase (Lgt) catalyzes the first step in the biogenesis of Gram-negative bacterial lipoproteins which play crucial roles in bacterial growth and pathogenesis. We demonstrate that Lgt depletion in...
2.
Clairfeuille T, Buchholz K, Li Q, Verschueren E, Liu P, Sangaraju D, et al.
Nature
. 2020 Aug;
584(7821):479-483.
PMID: 32788728
Lipopolysaccharide (LPS) resides in the outer membrane of Gram-negative bacteria where it is responsible for barrier function. LPS can cause death as a result of septic shock, and its lipid...
3.
Sande C, Bouwman C, Kell E, Nickerson N, Kapadia S, Whitfield C
J Bacteriol
. 2019 May;
201(14).
PMID: 31036729
Capsular polysaccharides (CPSs) are virulence factors for many important pathogens. In , CPSs are synthesized via two distinct pathways, but both require proteins from the outer membrane polysaccharide export (OPX)...
4.
Alexander M, Miu A, Oh A, Reichelt M, Ho H, Chalouni C, et al.
Antimicrob Agents Chemother
. 2018 Aug;
62(11).
PMID: 30104274
There is a critical need for new antibacterial strategies to counter the growing problem of antibiotic resistance. In Gram-negative bacteria, the outer membrane (OM) provides a protective barrier against antibiotics...
5.
Storek K, Auerbach M, Shi H, Garcia N, Sun D, Nickerson N, et al.
Proc Natl Acad Sci U S A
. 2018 Mar;
115(14):3692-3697.
PMID: 29555747
The folding and insertion of integral β-barrel membrane proteins into the outer membrane of Gram-negative bacteria is required for viability and bacterial pathogenesis. Unfortunately, the lack of selective and potent...
6.
Nickerson N, Jao C, Xu Y, Quinn J, Skippington E, Alexander M, et al.
Antimicrob Agents Chemother
. 2018 Jan;
62(4).
PMID: 29339384
The outer membrane is an essential structural component of Gram-negative bacteria that is composed of lipoproteins, lipopolysaccharides, phospholipids, and integral β-barrel membrane proteins. A dedicated machinery, called the Lol system,...
7.
Diao J, Bouwman C, Yan D, Kang J, Katakam A, Liu P, et al.
mBio
. 2017 May;
8(3).
PMID: 28536290
Murein lipoprotein (Lpp) and peptidoglycan-associated lipoprotein (Pal) are major outer membrane lipoproteins in Their roles in cell-envelope integrity have been documented in laboratory strains, and while Lpp has been linked...
8.
Cooper C, Mainprize I, Nickerson N
Adv Exp Med Biol
. 2015 Dec;
883:295-315.
PMID: 26621474
Surface polysaccharides are an often essential component of the outer surface of bacteria. They may serve to protect organisms from harsh environmental conditions and to increase virulence. The focus of...
9.
Huysmans G, Guilvout I, Chami M, Nickerson N, Pugsley A
Sci Rep
. 2015 Oct;
5:15068.
PMID: 26463896
Like several other large, multimeric bacterial outer membrane proteins (OMPs), the assembly of the Klebsiella oxytoca OMP PulD does not rely on the universally conserved β-barrel assembly machinery (BAM) that...
10.
Nickerson N, Mainprize I, Hampton L, Jones M, Naismith J, Whitfield C
Proc Natl Acad Sci U S A
. 2014 May;
111(22):8203-8.
PMID: 24843147
The outer membrane (OM) of Gram-negative bacteria is designed to exclude potentially harmful molecules. This property presents a challenge for bacteria that must secrete proteins and large glycoconjugates to grow,...