Nicholas J Savill
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Explore the profile of Nicholas J Savill including associated specialties, affiliations and a list of published articles.
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49
Citations
1103
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Recent Articles
21.
Mitchell K, Mutapi F, Savill N, Woolhouse M
Proc Natl Acad Sci U S A
. 2012 Aug;
109(33):13347-52.
PMID: 22847410
Protective immunity against human schistosome infection develops slowly, for reasons that are not yet fully understood. For many decades, researchers have attempted to infer properties of the immune response from...
22.
Howey R, Bankowski B, Juleff N, Savill N, Gibson D, Fazakerley J, et al.
Epidemics
. 2012 Jun;
4(2):93-103.
PMID: 22664068
In this paper we investigate the within-host dynamics of the foot-and-mouth disease virus (FMDV) in cattle using previously published data for 8 experimentally infected cows. An 8-compartment, 14-parameter differential equation...
23.
MacGregor P, Szoor B, Savill N, Matthews K
Nat Rev Microbiol
. 2012 May;
10(6):431-8.
PMID: 22543519
During their life cycle, trypanosomes must overcome conflicting demands to ensure their survival and transmission. First, they must evade immunity without overwhelming the host. Second, they must generate and maintain...
24.
Mideo N, Savill N, Chadwick W, Schneider P, Read A, Day T, et al.
Am Nat
. 2011 Nov;
178(6):E174-E188.
PMID: 22089879
Parasite strategies for exploiting host resources are key determinants of disease severity (i.e., virulence) and infectiousness (i.e., transmission between hosts). By iterating the development of theory and empirical tests, we...
25.
Atkins K, Read A, Savill N, Renz K, Walkden-Brown S, Woolhouse M
BMC Vet Res
. 2011 Nov;
7:70.
PMID: 22078942
Background: Marek's disease virus (MDV) is an economically important oncogenic herpesvirus of poultry. Since the 1960s, increasingly virulent strains have caused continued poultry industry production losses worldwide. To understand the...
26.
Mitchell K, Mutapi F, Savill N, Woolhouse M
PLoS Comput Biol
. 2011 Oct;
7(10):e1002237.
PMID: 22028640
Urogenital schistosomiasis is a tropical disease infecting more than 100 million people in sub-Saharan Africa. Individuals in endemic areas endure repeated infections with long-lived schistosome worms, and also encounter larval...
27.
Tildesley M, Gally D, McNeilly T, Low J, Mahajan A, Savill N
J R Soc Interface
. 2011 Aug;
9(68):518-27.
PMID: 21849385
Mathematical model-based statistical inference applied to within-host dynamics of infectious diseases can help dissect complex interactions between hosts and microbes. This work has applied advances in model-based inference to understand...
28.
MacGregor P, Savill N, Hall D, Matthews K
Cell Host Microbe
. 2011 Apr;
9(4):310-8.
PMID: 21501830
Sleeping sickness is characterized by waves of the extracellular parasite Trypanosoma brucei in host blood, with infections continuing for months or years until inevitable host death. These waves reflect the...
29.
Bessell P, Shaw D, Savill N, Woolhouse M
Epidemics
. 2011 Mar;
2(3):109-115.
PMID: 21352781
Controlling an epidemic would be aided by establishing whether particular individuals in infected populations are more likely to transmit infection. However, few analyses have characterised such individuals. Such analyses require...
30.
Singh B, Savill N, Ferguson N, Robertson C, Woolhouse M
BMC Public Health
. 2010 Nov;
10:726.
PMID: 21106071
Background: Key to the control of pandemic influenza are surveillance systems that raise alarms rapidly and sensitively. In addition, they must minimise false alarms during a normal influenza season. We...