Nicholas J Savill
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Explore the profile of Nicholas J Savill including associated specialties, affiliations and a list of published articles.
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49
Citations
1103
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Recent Articles
11.
Prior K, ODonnell A, Rund S, Savill N, van der Veen D, Reece S
Sci Rep
. 2019 Jul;
9(1):10905.
PMID: 31358780
Infection can dramatically alter behavioural and physiological traits as hosts become sick and subsequently return to health. Such "sickness behaviours" include disrupted circadian rhythms in both locomotor activity and body...
12.
Birget P, Prior K, Savill N, Steer L, Reece S
Malar J
. 2019 Jul;
18(1):222.
PMID: 31262304
Background: The ability of malaria (Plasmodium) parasites to adjust investment into sexual transmission stages versus asexually replicating stages is well known, but plasticity in other traits underpinning the replication rate...
13.
Greischar M, Reece S, Savill N, Mideo N
Trends Parasitol
. 2019 Apr;
35(5):341-355.
PMID: 30952484
Malaria infection is often accompanied by periodic fevers, triggered by synchronous cycles of parasite replication within the host. The degree of synchrony in parasite development influences the efficacy of drugs...
14.
Dewar C, MacGregor P, Cooper S, Gould M, Matthews K, Savill N, et al.
PLoS Pathog
. 2018 Jul;
14(7):e1007195.
PMID: 30020996
The sleeping sickness parasite Trypanosoma brucei has a complex life cycle, alternating between a mammalian host and the tsetse fly vector. A tightly controlled developmental programme ensures parasite transmission between...
15.
Prior K, van der Veen D, ODonnell A, Cumnock K, Schneider D, Pain A, et al.
PLoS Pathog
. 2018 Feb;
14(2):e1006900.
PMID: 29481559
Circadian rhythms enable organisms to synchronise the processes underpinning survival and reproduction to anticipate daily changes in the external environment. Recent work shows that daily (circadian) rhythms also enable parasites...
16.
Deardon R, Brooks S, Grenfell B, Keeling M, Tildesley M, Savill N, et al.
Stat Sin
. 2015 Sep;
20(1):239-261.
PMID: 26405426
Individual Level Models (ILMs), a new class of models, are being applied to infectious epidemic data to aid in the understanding of the spatio-temporal dynamics of infectious diseases. These models...
17.
Mitchell K, Mutapi F, Mduluza T, Midzi N, Savill N, Woolhouse M
PLoS Negl Trop Dis
. 2014 Aug;
8(7):e3059.
PMID: 25079601
Previous studies suggest that protective immunity against Schistosoma haematobium is primarily stimulated by antigens from dying worms. Praziquantel treatment kills adult worms, boosting antigen exposure and protective antibody levels. Current...
18.
Islam Z, Bishop S, Savill N, Rowland R, Lunney J, Trible B, et al.
PLoS One
. 2013 Dec;
8(12):e83567.
PMID: 24358295
Porcine reproductive and respiratory syndrome (PRRS) is one of the most economically significant viral diseases facing the global swine industry. Viremia profiles of PRRS virus challenged pigs reflect the severity...
19.
Atkins K, Read A, Walkden-Brown S, Savill N, Woolhouse M
Epidemics
. 2013 Nov;
5(4):208-17.
PMID: 24267877
Marek's disease virus (MDV), a poultry pathogen, has been increasing in virulence since the mid twentieth century. Since multiple vaccines have been developed and widely implemented, losses due to MDV...
20.
Atkins K, Read A, Savill N, Renz K, Islam A, Walkden-Brown S, et al.
Evolution
. 2013 Mar;
67(3):851-60.
PMID: 23461333
Marek's disease virus (MDV), a commercially important disease of poultry, has become substantially more virulent over the last 60 years. This evolution was presumably a consequence of changes in virus...