Nicholas J Savill
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Explore the profile of Nicholas J Savill including associated specialties, affiliations and a list of published articles.
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49
Citations
1103
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Recent Articles
1.
Meehan J, Ivens A, Grote S, Rodshagen T, Chen Z, Goode C, et al.
Nucleic Acids Res
. 2024 Aug;
52(19):11940-11959.
PMID: 39149912
Unknown factors regulate mitochondrial U-insertion/deletion (U-indel) RNA editing in procyclic-form (PCF) and bloodstream-form (BSF) T. brucei. This editing, directed by anti-sense gRNAs, creates canonical protein-encoding mRNAs and may developmentally control...
2.
Illius A, Savill N
Prev Vet Med
. 2024 Aug;
230:106297.
PMID: 39098260
The relative importance of maternal and horizontal transmission of small ruminant lentivirus (SRLV), the causative organism in maedi-visna, is poorly understood. Review of the literature shows that maternal transmission is...
3.
Meehan J, McDermott S, Ivens A, Goodall Z, Chen Z, Yu Z, et al.
Nucleic Acids Res
. 2023 May;
51(13):6944-6965.
PMID: 37246647
U-insertion/deletion (U-indel) RNA editing in trypanosome mitochondria is directed by guide RNAs (gRNAs). This editing may developmentally control respiration in bloodstream forms (BSF) and insect procyclic forms (PCF). Holo-editosomes include...
4.
Geerts M, Chen Z, Bebronne N, Savill N, Schnaufer A, Buscher P, et al.
NAR Genom Bioinform
. 2022 Oct;
4(4):lqac081.
PMID: 36285287
The World Health Organization targeted () human African trypanosomiasis for elimination of transmission by 2030. Sensitive molecular markers that specifically detect type 1 () parasites will be important tools to...
5.
Cooper S, Wadsworth E, Schnaufer A, Savill N
RNA
. 2022 Apr;
28(7):972-992.
PMID: 35414587
Mitochondrial DNA of protists of order comprises thousands of interlinked circular molecules arranged in a network. There are two types of molecules called minicircles and maxicircles. Minicircles encode guide RNA...
6.
Van den Broeck F, Savill N, Imamura H, Sanders M, Maes I, Cooper S, et al.
Proc Natl Acad Sci U S A
. 2020 Sep;
117(40):25159-25168.
PMID: 32958676
The tropical Andes are an important natural laboratory to understand speciation in many taxa. Here we examined the evolutionary history of parasites of the species complex based on whole-genome sequencing...
7.
Illius A, Lievaart-Peterson K, McNeilly T, Savill N
PLoS One
. 2020 Sep;
15(9):e0238781.
PMID: 32911525
Maedi-visna (MV) is a complex lentiviral disease syndrome characterised by long immunological and clinical latencies and chronic progressive inflammatory pathology. Incurable at the individual level, it is widespread in most...
8.
Macleod O, Bart J, MacGregor P, Peacock L, Savill N, Hester S, et al.
Nat Commun
. 2020 Mar;
11(1):1326.
PMID: 32165615
Persistent pathogens have evolved to avoid elimination by the mammalian immune system including mechanisms to evade complement. Infections with African trypanosomes can persist for years and cause human and animal...
9.
Savill N, Hogeweg P
J Theor Biol
. 2020 Jan;
184(3):229-235.
PMID: 31940735
We present a three-dimensional hybrid cellular automata (CA)/partial differential equation (PDE) model that allows for the study of morphogenesis in simple cellular systems. We apply the model to the cellular...
10.
Cooper S, Wadsworth E, Ochsenreiter T, Ivens A, Savill N, Schnaufer A
Nucleic Acids Res
. 2019 Oct;
47(21):11304-11325.
PMID: 31665448
Kinetoplastids are protists defined by one of the most complex mitochondrial genomes in nature, the kinetoplast. In the sleeping sickness parasite Trypanosoma brucei, the kinetoplast is a chain mail-like network...