Nicholas Hoe
Overview
Explore the profile of Nicholas Hoe including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
358
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Recent Articles
1.
Xu-Monette Z, Xiao M, Au Q, Padmanabhan R, Xu B, Hoe N, et al.
Cancer Immunol Res
. 2019 Feb;
7(4):644-657.
PMID: 30745366
PD-1/L1 and CTLA-4 blockade immunotherapies have been approved for 13 types of cancers and are being studied in diffuse large B-cell lymphoma (DLBCL), the most common aggressive B-cell lymphoma. However,...
2.
Curtis C, Landis G, Folk D, Wehr N, Hoe N, Waskar M, et al.
Genome Biol
. 2016 May;
17(1):93.
PMID: 27154433
No abstract available.
3.
Abbasi Asbagh L, Vazquez I, Vecchione L, Budinska E, De Vriendt V, Baietti M, et al.
Oncotarget
. 2014 Oct;
5(20):10070-83.
PMID: 25301722
Inappropriate activation of epidermal growth factor receptor (EGFR) plays a causal role in many cancers including colon cancer. The activation of EGFR by phosphorylation is balanced by receptor kinase and...
4.
Lee J, Kim S, Kim P, Liu X, Lee T, Kim K, et al.
PLoS One
. 2013 Feb;
8(1):e54644.
PMID: 23372746
Purpose: The aim of this study was to utilize the proteomics-based Collaborative Enzyme Enhanced Reactive (CEER) immunoassay to investigate protein tyrosine phosphorylations as diagnostic markers in gastric cancers (GCs). Experimental...
5.
Jegg A, Ward T, Iorns E, Hoe N, Zhou J, Liu X, et al.
Breast Cancer Res Treat
. 2012 Oct;
136(3):683-92.
PMID: 23089982
Therapies targeting the ERBB2 receptor, including the kinase inhibitor lapatinib (Tykerb, GlaxoSmithKline), have improved clinical outcome for women with ERBB2-amplified breast cancer. However, acquired resistance to lapatinib remains a significant...
6.
Hoe N, Huang C, Landis G, Verhage M, Ford D, Yang J, et al.
Aging (Albany NY)
. 2011 Mar;
3(3):237-61.
PMID: 21415465
Molecular Misreading (MM) is the inaccurate conversion of genomic information into aberrant proteins. For example, when RNA polymerase II transcribes a GAGAG motif it synthesizes at low frequency RNA with...
7.
Grover D, Ford D, Brown C, Hoe N, Erdem A, Tavare S, et al.
PLoS One
. 2009 Oct;
4(10):e7580.
PMID: 19862323
Circadian rhythms in animals are regulated at the level of individual cells and by systemic signaling to coordinate the activities of multiple tissues. The circadian pacemakers have several physiological outputs,...
8.
Pabarcus M, Hoe N, Sadeghi S, Patterson C, Wiertz E, Correia M
Arch Biochem Biophys
. 2008 Dec;
483(1):66-74.
PMID: 19103148
Human liver CYP3A4 is an endoplasmic reticulum (ER)-anchored hemoprotein responsible for the metabolism of >50% of clinically prescribed drugs. After heterologous expression in Saccharomyces cerevisiae, it is degraded via the...
9.
Wang Y, Liao M, Hoe N, Acharya P, Deng C, Krutchinsky A, et al.
J Biol Chem
. 2008 Dec;
284(9):5671-84.
PMID: 19095658
Cytochromes P450 (P450s) incur phosphorylation. Although the precise role of this post-translational modification is unclear, marking P450s for degradation is plausible. Indeed, we have found that after structural inactivation, CYP3A4,...
10.
Curtis C, Landis G, Folk D, Wehr N, Hoe N, Waskar M, et al.
Genome Biol
. 2007 Dec;
8(12):R262.
PMID: 18067683
Background: Several interventions increase lifespan in model organisms, including reduced insulin/insulin-like growth factor-like signaling (IIS), FOXO transcription factor activation, dietary restriction, and superoxide dismutase (SOD) over-expression. One question is whether...