Nicholas H Keep
Overview
Explore the profile of Nicholas H Keep including associated specialties, affiliations and a list of published articles.
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35
Citations
1083
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Recent Articles
1.
Munshi T, Gupta A, Evangelopoulos D, Guzman J, Gibbons S, Keep N, et al.
PLoS One
. 2024 Mar;
19(3):e0301375.
PMID: 38530839
[This corrects the article DOI: 10.1371/journal.pone.0060143.].
2.
Roddan R, Sula A, Mendez-Sanchez D, Subrizi F, Lichman B, Broomfield J, et al.
Commun Chem
. 2023 Jan;
3(1):170.
PMID: 36703392
The 1-aryl-tetrahydroisoquinoline (1-aryl-THIQ) moiety is found in many biologically active molecules. Single enantiomer chemical syntheses are challenging and although some biocatalytic routes have been reported, the substrate scope is limited...
3.
Roddan R, Subrizi F, Broomfield J, Ward J, Keep N, Hailes H
Org Lett
. 2021 Aug;
23(16):6342-6347.
PMID: 34355910
Tetrahydroprotoberberine and protoberberine alkaloids are a group of biologically active natural products with complex molecular scaffolds. Isolation from plants is challenging and stereoselective synthetic routes, particularly of methylated compounds are...
4.
Maitra A, Nukala S, Dickman R, Martin L, Munshi T, Gupta A, et al.
JAC Antimicrob Resist
. 2021 Jul;
3(1):dlab028.
PMID: 34223102
Objectives: Identification and validation of novel therapeutic targets is imperative to tackle the rise of drug resistance in tuberculosis. An essential Mur ligase-like gene (Rv3712), expected to be involved in...
5.
Nelson A, Phipps R, Crane G, Venanzi N, Lockley W, Tredwell M, et al.
J Labelled Comp Radiopharm
. 2020 Jul;
:608-617.
PMID: 32678462
No abstract available.
6.
Roddan R, Ward J, Keep N, Hailes H
Curr Opin Chem Biol
. 2020 Jan;
55:69-76.
PMID: 31978651
Pictet-Spenglerases provide a key role in the biosynthesis of many biologically active alkaloids. There is increasing use of these biocatalysts as an alternative to traditional organic synthetic methods as they...
7.
Ziveri J, Chhuon C, Jamet A, Rytter H, Prigent G, Tros F, et al.
Mol Cell Proteomics
. 2019 Oct;
18(12):2418-2432.
PMID: 31578219
The bacterial pathogen possesses a noncanonical type VI secretion system (T6SS) that is required for phagosomal escape in infected macrophages. KCl stimulation has been previously used to trigger assembly and...
8.
Cell wall peptidoglycan in Mycobacterium tuberculosis: An Achilles' heel for the TB-causing pathogen
Maitra A, Munshi T, Healy J, Martin L, Vollmer W, Keep N, et al.
FEMS Microbiol Rev
. 2019 Jun;
43(5):548-575.
PMID: 31183501
Tuberculosis (TB), caused by the intracellular pathogen Mycobacterium tuberculosis, remains one of the leading causes of mortality across the world. There is an urgent requirement to build a robust arsenal...
9.
Clark A, Vree Egberts W, Kondrat F, Hilton G, Ray N, Cole A, et al.
J Mol Biol
. 2018 Jul;
430(18 Pt B):3297-3310.
PMID: 29969581
Heterogeneity in small heat shock proteins (sHsps) spans multiple spatiotemporal regimes-from fast fluctuations of part of the protein, to conformational variability of tertiary structure, plasticity of the interfaces, and polydispersity...
10.
Lichman B, Sula A, Pesnot T, Hailes H, Ward J, Keep N
Biochemistry
. 2017 Sep;
56(40):5274-5277.
PMID: 28915025
Norcoclaurine synthase (NCS) is a Pictet-Spenglerase that catalyzes the first key step in plant benzylisoquinoline alkaloid metabolism, a compound family that includes bioactive natural products such as morphine. The enzyme...