Nicholas G S McGregor
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Explore the profile of Nicholas G S McGregor including associated specialties, affiliations and a list of published articles.
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15
Citations
75
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Recent Articles
1.
Pickles I, Chen Y, Moroz O, Brown H, de Boer C, Armstrong Z, et al.
Angew Chem Int Ed Engl
. 2024 Nov;
64(5):e202415219.
PMID: 39601378
α-Amylases are the workhorse enzymes of starch degradation. They are central to human health, including as targets for anti-diabetic compounds, but are also the key enzymes in the industrial processing...
2.
Caseiro C, McGregor N, Alves V, Carvalho A, Romao M, Davies G, et al.
Int J Biol Macromol
. 2024 Nov;
282(Pt 6):137402.
PMID: 39528173
The structural and chemical diversity of β-glucans is reflected on the variety of essential biological roles tackled by these polysaccharides. This natural heterogeneity requires an elaborate assortment of enzymatic mechanisms...
3.
McGregor N, Penttila P, Pitkanen L, Mohammadi P, Vuorte M, Igarashi K, et al.
Carbohydr Polym
. 2024 Nov;
347:122703.
PMID: 39486944
Mixed-linkage glucans are major components of grassy cell-walls and cereal endosperm. Recently identified plant endo-β-glucanase from the EG16 family cleaves MLGs with strong specificity towards regions with at least four...
4.
Scott C, McGregor N, Leadbeater D, Oates N, Hossbach J, Abood A, et al.
Microbiol Spectr
. 2024 May;
12(7):e0394323.
PMID: 38757984
NO1 is a plant biomass-degrading ascomycete with a propensity to target the most recalcitrant components of lignocellulose. Here we applied proteomics and activity-based protein profiling (ABPP) to investigate the ability...
5.
McGregor N, de Boer C, Foucart Q, Beenakker T, Offen W, Codee J, et al.
ACS Cent Sci
. 2024 Jan;
9(12):2306-2314.
PMID: 38161374
Bacteria and yeasts grow on biomass polysaccharides by expressing and excreting a complex array of glycoside hydrolase (GH) enzymes. Identification and annotation of such GH pools, which are valuable commodities...
6.
Scott C, Leadbeater D, Oates N, James S, Newling K, Li Y, et al.
Microbiol Spectr
. 2023 Oct;
11(6):e0103523.
PMID: 37811978
An annotated reference genome has revealed NO1 as a useful resource for the identification of new lignocellulose-degrading enzymes for biorefining of woody plant biomass. Utilizing a "structure-omics"-based searching strategy, we...
7.
McGregor N, de Boer C, Santos M, Haon M, Navarro D, Schroder S, et al.
Biotechnol Biofuels Bioprod
. 2022 Apr;
15(1):6.
PMID: 35418096
Background: Fungal saccharification of lignocellulosic biomass occurs concurrently with the secretion of a diverse collection of proteins, together functioning as a catalytic system to liberate soluble sugars from insoluble composite...
8.
McGregor N, Overkleeft H, Davies G
Methods Enzymol
. 2022 Mar;
664:103-134.
PMID: 35331370
The ability to detect active enzymes in a complex mixture of folded proteins (e.g., secretome, cell lysate) generally relies on observations of catalytic ability, necessitating the development of an activity...
9.
McGregor N, Kuo C, Beenakker T, Wong C, Offen W, Armstrong Z, et al.
Org Biomol Chem
. 2022 Jan;
20(4):877-886.
PMID: 35015006
-β-mannosidases are a broad class of stereochemically retaining hydrolases that are essential for the breakdown of complex carbohydrate substrates found in all kingdoms of life. Yet the detection of -β-mannosidases...
10.
de Boer C, McGregor N, Peterse E, Schroder S, Florea B, Jiang J, et al.
RSC Chem Biol
. 2022 Jan;
2(6):1701.
PMID: 34977585
[This corrects the article DOI: 10.1039/D0CB00045K.].