Nicholas G Davis
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Explore the profile of Nicholas G Davis including associated specialties, affiliations and a list of published articles.
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1604
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Recent Articles
1.
Roth A, Davis N
EMBO J
. 2020 Mar;
39(8):e104744.
PMID: 32202660
Protein prenylation, a well-defined protein consensus motifs direct modification by one of three prenyl-transferases, has been an area of fairly settled science for 20 or 30 years. Protein prenylation, the...
2.
Lin D, Davis N, Conibear E
Biochem Soc Trans
. 2017 Jun;
45(4):913-921.
PMID: 28630138
The Ras proteins are well-known drivers of many cancers and thus represent attractive targets for the development of anticancer therapeutics. Inhibitors that disrupt the association of the Ras proteins with...
3.
Henderson M, Wirak G, Zhang Y, Dai F, Ginsberg S, Dolzhanskaya N, et al.
Acta Neuropathol
. 2015 Dec;
131(4):621-37.
PMID: 26659577
Neuronal ceroid lipofuscinoses (NCL) are a group of inherited neurodegenerative disorders with lysosomal pathology (CLN1-14). Recently, mutations in the DNAJC5/CLN4 gene, which encodes the presynaptic co-chaperone CSPα were shown to...
4.
Davis N, Houston D, Nason J
Appl Plant Sci
. 2015 Jul;
3(7).
PMID: 26191464
Premise Of The Study: Single-nucleotide polymorphism (SNP) primers were developed for a native North American desert fig, Ficus petiolaris (Moraceae), to provide markers for population genetic studies designed to quantify...
5.
Wan J, Savas J, Roth A, Sanders S, Singaraja R, Hayden M, et al.
Chem Biol
. 2013 Nov;
20(11):1421-34.
PMID: 24211138
Protein palmitoylation, a reversible lipid modification of proteins, is widely used in the nervous system, with dysregulated palmitoylation being implicated in a variety of neurological disorders. Described below is ABE/SILAM,...
6.
Singaraja R, Huang K, Sanders S, Milnerwood A, Hines R, Lerch J, et al.
Hum Mol Genet
. 2011 Jul;
20(20):3899-909.
PMID: 21775500
Huntingtin interacting protein 14 (HIP14, ZDHHC17) is a huntingtin (HTT) interacting protein with palmitoyl transferase activity. In order to interrogate the function of Hip14, we generated mice with disruption in...
7.
Roth A, Papanayotou I, Davis N
Mol Biol Cell
. 2011 Jun;
22(15):2702-15.
PMID: 21653825
The yeast kinase Yck2 tethers to the cytoplasmic surface of the plasma membrane through dual palmitoylation of its C-terminal Cys-Cys dipeptide, mediated by the Golgi-localized palmitoyl-transferase Akr1. Here, the Yck2...
8.
Huang K, Sanders S, Kang R, Carroll J, Sutton L, Wan J, et al.
Hum Mol Genet
. 2011 Jun;
20(17):3356-65.
PMID: 21636527
Huntington disease (HD) is caused by polyglutamine expansion in the huntingtin (HTT) protein. Huntingtin-interacting protein 14 (HIP14), one of 23 DHHC domain-containing palmitoyl acyl transferases (PATs), binds to HTT and...
9.
Conibear E, Davis N
J Cell Sci
. 2010 Nov;
123(Pt 23):4007-10.
PMID: 21084560
No abstract available.
10.
Huang K, Kang M, Askew C, Kang R, Sanders S, Wan J, et al.
Neurobiol Dis
. 2010 Aug;
40(1):207-15.
PMID: 20685337
Excitotoxicity plays a key role in the selective vulnerability of striatal neurons in Huntington disease (HD). Decreased glutamate uptake by glial cells could account for the excess glutamate at the...