Altered Palmitoylation and Neuropathological Deficits in Mice Lacking HIP14

Overview

Journal Hum Mol Genet

Specialties Genetics
Molecular Biology

Date 2011 Jul 22

PMID 21775500

Citations 63

Authors

Roshni R Singaraja

Kun Huang

Shaun S Sanders

Austen J Milnerwood

Rochelle Hines

Jason P Lerch

Sonia Franciosi

Renaldo C Drisdel

Kuljeet Vaid

Fiona B Young

Crystal Doty

Junmei Wan

Nagat Bissada

R Mark Henkelman

William N Green

Nicholas G Davis

Lynn A Raymond

Michael R Hayden

Affiliations

Soon will be listed here.

Abstract

Huntingtin interacting protein 14 (HIP14, ZDHHC17) is a huntingtin (HTT) interacting protein with palmitoyl transferase activity. In order to interrogate the function of Hip14, we generated mice with disruption in their Hip14 gene. Hip14-/- mice displayed behavioral, biochemical and neuropathological defects that are reminiscent of Huntington disease (HD). Palmitoylation of other HIP14 substrates, but not Htt, was reduced in the Hip14-/- mice. Hip14 is dysfunctional in the presence of mutant htt in the YAC128 mouse model of HD, suggesting that altered palmitoylation mediated by HIP14 may contribute to HD.

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