Nicholas Denko
Overview
Explore the profile of Nicholas Denko including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
380
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0
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Recent Articles
1.
Malekan M, Denko N, Mortara L, Rathinavelu A, Parvizi M, Natarajan U
Front Pharmacol
. 2024 Aug;
15:1448204.
PMID: 39193323
No abstract available.
2.
Dravillas C, Coleman 4th S, Hoyd R, Caryotakis G, Denko L, Chan C, et al.
Cancer Res Commun
. 2024 Jul;
4(8):1978-1990.
PMID: 39015091
Significance: We analyzed the tumor microbiome and interactions with genes and pathways in metastatic melanoma treated with immunotherapy and identified several microbes associated with immunotherapy response and immune-related gene expression...
3.
Benej M, Hoyd R, Kreamer M, Wheeler C, Grencewicz D, Choueiry F, et al.
Cancer Res Commun
. 2024 Jun;
4(7):1690-1701.
PMID: 38904265
Significance: Tumor hypoxia reduces radiotherapy efficacy. In this study, we explored whether some of the clinical effects of hypoxia could be due to interaction with the tumor microbiome. Hypoxic gene...
4.
Wolfe A, Cui T, Baie S, Corrales-Guerrero S, Webb A, Castro-Aceituno V, et al.
Sci Adv
. 2024 Mar;
10(9):eadj3551.
PMID: 38427741
Pancreatic ductal adenocarcinoma (PDAC) is characterized by its nutrient-scavenging ability, crucial for tumor progression. Here, we investigated the roles of caveolae-mediated endocytosis (CME) in PDAC progression. Analysis of patient data...
5.
Wang C, Ma A, Li Y, McNutt M, Zhang S, Zhu J, et al.
Cancer Res Commun
. 2024 Jan;
4(2):293-302.
PMID: 38259095
Significance: Studying the tumor microbiome in high-throughput sequencing data is challenging because of the extremely sparse data matrices, heterogeneity, and high likelihood of contamination. We present a new deep learning...
6.
Wang C, Ma A, McNutt M, Hoyd R, Wheeler C, Robinson L, et al.
bioRxiv
. 2023 Jun;
PMID: 37292990
Evidence supports significant interactions among microbes, immune cells, and tumor cells in at least 10-20% of human cancers, emphasizing the importance of further investigating these complex relationships. However, the implications...
7.
Wheeler C, Coleman 4th S, Hoyd R, Denko L, Chan C, Churchman M, et al.
bioRxiv
. 2023 Jun;
PMID: 37292921
Emerging evidence supports the important role of the tumor microbiome in oncogenesis, cancer immune phenotype, cancer progression, and treatment outcomes in many malignancies. In this study, we investigated the metastatic...
8.
Viswanathan V, Cao H, Saiki J, Jiang D, Mattingly A, Nambiar D, et al.
PNAS Nexus
. 2022 Jun;
1(2):pgac056.
PMID: 35707206
Adult salivary stem/progenitor cells (SSPC) have an intrinsic property to self-renew in order to maintain tissue architecture and homeostasis. Adult salivary glands have been documented to harbor SSPC, which have...
9.
Alagappan M, Jiang D, Denko N, Koong A
Adv Exp Med Biol
. 2016 Jun;
899:253-68.
PMID: 27325272
In silico drug discovery refers to a combination of computational techniques that augment our ability to discover drug compounds from compound libraries. Many such techniques exist, including virtual high-throughput screening...
10.
Cerniglia G, Dey S, Gallagher-Colombo S, Daurio N, Tuttle S, Busch T, et al.
Mol Cancer Ther
. 2015 May;
14(8):1928-38.
PMID: 25995437
Inhibition of the PI3K/Akt pathway decreases hypoxia within SQ20B human head and neck cancer xenografts. We set out to understand the molecular mechanism underlying this observation. We measured oxygen consumption...