Nicholas D Leigh
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Explore the profile of Nicholas D Leigh including associated specialties, affiliations and a list of published articles.
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22
Citations
740
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Recent Articles
1.
Brown T, Mishra K, Elewa A, Iarovenko S, Subramanian E, Araus A, et al.
Cell Genom
. 2025 Jan;
5(2):100761.
PMID: 39874962
Newts have large genomes harboring many repeat elements. How these elements shape the genome and relate to newts' unique regeneration ability remains unknown. We present here the chromosome-scale assembly of...
2.
Oesterle M, Leigh N
Cell Reprogram
. 2024 May;
26(3):91-92.
PMID: 38717852
Cellular senescence is a state in which cells enter cell cycle arrest. However, senescent cells have the ability to secrete signaling molecules such as chemokines, cytokines, and growth factors. This...
3.
Cardiello J, Araus A, Giatrellis S, Helsens C, Simon A, Leigh N
Life Sci Alliance
. 2023 May;
6(8).
PMID: 37197983
Single-cell sequencing (sc-seq) provides a species agnostic tool to study cellular processes. However, these technologies are expensive and require sufficient cell quantities and biological replicates to avoid artifactual results. An...
4.
Dunlap G, Leigh N
Methods Mol Biol
. 2022 Oct;
2562:461-469.
PMID: 36272094
The dramatic increase in accessibility to sequencing technologies has opened new avenues into studying different processes, cells, and animal models. In the amphibian models used for regeneration research, these new...
5.
Woych J, Gurrola A, Deryckere A, Jaeger E, Gumnit E, Merello G, et al.
Science
. 2022 Sep;
377(6610):eabp9186.
PMID: 36048957
The evolution of advanced cognition in vertebrates is associated with two independent innovations in the forebrain: the six-layered neocortex in mammals and the dorsal ventricular ridge (DVR) in sauropsids (reptiles...
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Wijk S, Prabhala P, Michalikova B, Sommarin M, Doyle A, Lang S, et al.
Am J Respir Cell Mol Biol
. 2021 Mar;
65(1):103-113.
PMID: 33789072
Airway basal cells are crucial for regeneration of the human lung airway epithelium and are believed to be important contributors to chronic obstructive pulmonary disease (COPD) and other lung disorders....
9.
Stegmayr J, Alsafadi H, Langwinski W, Niroomand A, Lindstedt S, Leigh N, et al.
Am J Physiol Lung Cell Mol Physiol
. 2020 Oct;
320(2):L232-L240.
PMID: 33112185
Precision-cut lung slices (PCLS) have gained increasing interest as a model to study lung biology/disease and screening novel therapeutics. In particular, PCLS derived from human tissue can better recapitulate some...
10.
Leigh N, Sessa S, Dragalzew A, Payzin-Dogru D, Sousa J, Aggouras A, et al.
Evol Dev
. 2020 Mar;
22(4):297-311.
PMID: 32163674
Regenerative ability varies tremendously across species. A common feature of regeneration of appendages such as limbs, fins, antlers, and tails is the formation of a blastema-a transient structure that houses...