Nicholas D Holliday
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Explore the profile of Nicholas D Holliday including associated specialties, affiliations and a list of published articles.
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44
Citations
717
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Recent Articles
1.
Ertl F, Kopanchuk S, Dijon N, Veiksina S, Tahk M, Laasfeld T, et al.
J Med Chem
. 2024 Sep;
67(18):16664-16691.
PMID: 39261089
The determination of ligand-receptor binding affinities plays a key role in the development process of pharmaceuticals. While the classical radiochemical binding assay uses radioligands, fluorescence-based binding assays require fluorescent probes....
2.
Pinto M, Sirina J, Holliday N, McWhirter C
SLAS Discov
. 2024 Jul;
29(5):100170.
PMID: 38964171
The importance of a drug's kinetic profile and interplay of structure-kinetic activity with PK/PD has long been appreciated in drug discovery. However, technical challenges have often limited detailed kinetic characterization...
3.
Talamonti E, Davegardh J, Kalinovich A, van Beek S, Dehvari N, Halleskog C, et al.
Mol Metab
. 2024 May;
85:101931.
PMID: 38796310
Objective: Simultaneous activation of β2- and β3-adrenoceptors (ARs) improves whole-body metabolism via beneficial effects in skeletal muscle and brown adipose tissue (BAT). Nevertheless, high-efficacy agonists simultaneously targeting these receptors whilst...
4.
Ham S, Mukaida S, Sato M, Keov P, Bengtsson T, Furness S, et al.
Pharmacol Res Perspect
. 2024 Feb;
12(1):e1176.
PMID: 38332691
Truncation of the C-terminal tail of the β -AR, transfection of βARKct or over-expression of a kinase-dead GRK mutant reduces isoprenaline-stimulated glucose uptake, indicating that GRK is important for this...
5.
Mitchell-White J, Briggs D, Mistry S, Mbiwan H, Kellam B, Holliday N, et al.
Arch Biochem Biophys
. 2024 Feb;
753:109915.
PMID: 38307314
The human ATP-binding cassette (ABC) transporter, ABCG2, is responsible for multidrug resistance in some tumours. Detailed knowledge of its activity is crucial for understanding drug transport and resistance in cancer,...
6.
Alexander S, Christopoulos A, Davenport A, Kelly E, Mathie A, Peters J, et al.
Br J Pharmacol
. 2023 Dec;
180 Suppl 2:S23-S144.
PMID: 38123151
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of...
7.
Hoare B, Tippett D, Kaur A, Cullum S, Miljus T, Koers E, et al.
Chembiochem
. 2023 Oct;
25(2):e202300459.
PMID: 37872746
Measurements of membrane protein thermostability reflect ligand binding. Current thermostability assays often require protein purification or rely on pre-existing radiolabelled or fluorescent ligands, limiting their application to established targets. Alternative...
8.
Casella B, Farmer J, Nesheva D, Williams H, Charlton S, Holliday N, et al.
J Med Chem
. 2023 Jul;
66(18):12911-12930.
PMID: 37523859
The inhibition of CXC chemokine receptor 2 (CXCR2), a key inflammatory mediator, is a potential strategy in the treatment of several pulmonary diseases and cancers. The complexity of endogenous chemokine...
9.
Stockley M, Benedetti G, Blencowe P, Boulton S, Boyd S, Calder M, et al.
J Med Chem
. 2023 Feb;
PMID: 36815444
No abstract available.
10.
Gibbs M, Winnig M, Riva I, Dunlop N, Waller D, Klebansky B, et al.
PLoS One
. 2022 Nov;
17(11):e0277607.
PMID: 36449493
As the most favoured animal companion of humans, dogs occupy a unique place in society. Understanding the senses of the dog can bring benefits to both the dogs themselves and...