Nicholas C Zachos
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Explore the profile of Nicholas C Zachos including associated specialties, affiliations and a list of published articles.
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79
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3395
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Recent Articles
1.
Holowatyj A, Overman M, Votanopoulos K, Lowy A, Wagner P, Washington M, et al.
Nat Rev Cancer
. 2025 Feb;
PMID: 39979656
Tumours of the appendix - a vestigial digestive organ attached to the colon - are rare. Although we estimate that around 3,000 new appendiceal cancer cases are diagnosed annually in...
2.
Donowitz M, Tse C, Sarker R, Lin R, Dokladny K, Rawat M, et al.
Cell Mol Gastroenterol Hepatol
. 2024 Aug;
18(5):101383.
PMID: 39089626
Background & Aims: Diarrhea occurs in up to 50% of cases of COVID-19. Nonetheless, the pathophysiologic mechanism(s) have not been determined. Methods: This was examined using normal human enteroid monolayers...
3.
Zachos N, Vaughan H, Sarker R, Est-Witte S, Chakraborty M, Baetz N, et al.
Gastroenterology
. 2023 Jul;
165(4):986-998.e11.
PMID: 37429363
Background & Aims: Acute diarrheal diseases are the second most common cause of infant mortality in developing countries. This is contributed to by lack of effective drug therapy that shortens...
4.
Staab J, Lemme-Dumit J, Latanich R, Pasetti M, Zachos N
Methods Mol Biol
. 2023 Jun;
2650:207-223.
PMID: 37310634
The coordinated interaction between the intestinal epithelium and immune cells is required to maintain proper barrier function and mucosal host defenses to the harsh external environment of the gut lumen....
5.
Maeda K, Bugda Gwilt K, Schmieder S, Zachos N, Lencer W
STAR Protoc
. 2023 May;
4(2):102335.
PMID: 37243601
Transcytosis is the primary mechanism by which macro-molecules transverse epithelial cell barriers. Here, we present an assay for measuring transcytosis and recycling of IgG in intestinal epithelial Caco-2 cells and...
6.
Bouffi C, Wikenheiser-Brokamp K, Chaturvedi P, Sundaram N, Goddard G, Wunderlich M, et al.
Nat Biotechnol
. 2023 Jan;
41(6):824-831.
PMID: 36702898
Human intestinal organoids (HIOs) derived from pluripotent stem cells provide a valuable model for investigating human intestinal organogenesis and physiology, but they lack the immune components required to fully recapitulate...
7.
Laky K, Kinard J, Li J, Moore I, Lack J, Fischer E, et al.
Sci Immunol
. 2023 Jan;
8(79):eabp9940.
PMID: 36608150
Allergic diseases are a global health challenge. Individuals harboring loss-of-function variants in transforming growth factor-β receptor (TGFβR) genes have an increased prevalence of allergic disorders, including eosinophilic esophagitis. Allergic diseases...
8.
Boardman D, Wong M, Rees W, Wu D, Himmel M, Orban P, et al.
J Autoimmun
. 2022 Dec;
134:102961.
PMID: 36470208
Regulatory T cell (Treg) therapy is a promising strategy to treat inflammatory bowel disease (IBD). Data from animal models has shown that Tregs specific for intestinal antigens are more potent...
9.
Lemme-Dumit J, Doucet M, Zachos N, Pasetti M
mBio
. 2022 Jun;
13(3):e0094422.
PMID: 35652591
Polymorphonuclear neutrophils (PMN) are recruited to the gastrointestinal mucosa in response to inflammation, injury, and infection. Here, we report the development and the characterization of an tissue coculture model consisting...
10.
Pearce S, Karl J, Zachos N
Front Physiol
. 2022 Apr;
13:894922.
PMID: 35464094
No abstract available.