Mark Donowitz
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Explore the profile of Mark Donowitz including associated specialties, affiliations and a list of published articles.
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5856
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Recent Articles
1.
Rong Y, Zhang Z, De Jonge H, Lin R, Yu H, Sarker R, et al.
bioRxiv
. 2025 Feb;
PMID: 39975121
Constipation causes significant morbidity in Cystic Fibrosis (CF) patients. Using CF patient (F508del) derived ileal and distal colonic/rectal enteroids as a model and the Forskolin Induced Swelling Assay (FIS), we...
2.
Arian C, OMahony E, MacDonald J, Bammler T, Donowitz M, Kelly E, et al.
Drug Metab Dispos
. 2025 Jan;
53(1):100002.
PMID: 39884814
To further the development of an in vitro model that faithfully recapitulates drug disposition of orally administered drugs, we investigated the utility of human enteroid monolayers to simultaneously assess intestinal...
3.
Sheikh A, Ganguli D, Vickers T, Singer B, Foulke-Abel J, Akhtar M, et al.
Proc Natl Acad Sci U S A
. 2024 Sep;
121(38):e2410679121.
PMID: 39264739
Enterotoxigenic (ETEC) cause hundreds of millions of diarrheal illnesses annually ranging from mildly symptomatic cases to severe, life-threatening cholera-like diarrhea. Although ETEC are associated with long-term sequelae including malnutrition, the...
4.
Sheikh A, Ganguli D, Vickers T, Singer B, Foulke-Abel J, Akhtar M, et al.
bioRxiv
. 2024 Aug;
PMID: 39091797
Enterotoxigenic (ETEC) cause hundreds of millions of diarrheal illnesses annually ranging from mildly symptomatic cases to severe, life-threatening cholera-like diarrhea. Although ETEC are associated with long-term sequelae including malnutrition, the...
5.
Donowitz M, Tse C, Sarker R, Lin R, Dokladny K, Rawat M, et al.
Cell Mol Gastroenterol Hepatol
. 2024 Aug;
18(5):101383.
PMID: 39089626
Background & Aims: Diarrhea occurs in up to 50% of cases of COVID-19. Nonetheless, the pathophysiologic mechanism(s) have not been determined. Methods: This was examined using normal human enteroid monolayers...
6.
Type 1 diabetes human enteroid studies reveal major changes in the intestinal epithelial compartment
Bharadiya V, Rong Y, Zhang Z, Lin R, Guerrerio A, Tse C, et al.
Sci Rep
. 2024 May;
14(1):11911.
PMID: 38789719
Lack of understanding of the pathophysiology of gastrointestinal (GI) complications in type 1 diabetes (T1D), including altered intestinal transcriptomes and protein expression represents a major gap in the management of...
7.
Dong Y, Johnson B, Ruan L, Zeineldin M, Bi T, Liu A, et al.
Sci Adv
. 2024 Apr;
10(14):eadj7666.
PMID: 38569041
Inflammation-associated fibroblasts (IAFs) are associated with progression and drug resistance of chronic inflammatory diseases such as inflammatory bowel disease (IBD), but their direct impact on epithelial cells is unknown. Here,...
8.
Dong Y, Johnson B, Ruan L, Zeineldin M, Liu A, Raychaudhuri S, et al.
bioRxiv
. 2023 Oct;
PMID: 37808771
Inflammation-associated fibroblasts (IAFs) are associated with the progression and drug resistance of chronic inflammatory diseases such as inflammatory bowel disease (IBD), but their direct impact on epithelial function and architecture...
9.
Smyth J, Truong J, Rao A, Lin R, Foulke-Abel J, Adorini L, et al.
Am J Physiol Gastrointest Liver Physiol
. 2023 Sep;
325(5):G446-G452.
PMID: 37697930
Intestinal inflammation and diarrhea are often associated with SARS-CoV-2 infection. The angiotensin converting enzyme 2 (ACE2) receptor plays a key role in SARS-CoV-2 pathogenesis, facilitating entry of the virus into...
10.
Chu T, Yottasan P, de Souza Goncalves L, Oak A, Lin R, Tse M, et al.
Transl Res
. 2023 Sep;
263:45-52.
PMID: 37678755
Cyclic nucleotide elevation in intestinal epithelial cells is the key pathology causing intestinal fluid loss in secretory diarrheas such as cholera. Current secretory diarrhea treatment is primarily supportive, and oral...