Nicholas Barlow
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Explore the profile of Nicholas Barlow including associated specialties, affiliations and a list of published articles.
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26
Citations
537
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Recent Articles
1.
Stam F, Bjurling S, Nylander E, Olaniran Hakansson E, Barlow N, Gising J, et al.
Int J Mol Sci
. 2024 Nov;
25(22).
PMID: 39596085
The insulin-regulated aminopeptidase (IRAP; oxytocinase) is part of the M1 aminopeptidase family and is highly expressed in many tissues, including the neocortex and hippocampus of the brain. IRAP is involved...
2.
Mansouri M, Rumrill S, Dawson S, Johnson A, Pinson J, Gunzburg M, et al.
Molecules
. 2023 Apr;
28(7).
PMID: 37049868
Human immunodeficiency virus type I (HIV-1) is a retrovirus that infects cells of the host's immune system leading to acquired immunodeficiency syndrome and potentially death. Although treatments are available to...
3.
Yue W, Zhang T, Shandre Mugan R, Barlow N, Chalmers D, Pouton C, et al.
J Med Chem
. 2023 Feb;
66(5):3273-3283.
PMID: 36808973
While a range of strategies exist to accomplish peptide macrocyclization, they are frequently limited by the need for orthogonal protection or provide little opportunity for structural diversification. We have evaluated...
4.
Mussmann B, Milner R, Barlow N, Jensen J
Radiography (Lond)
. 2022 Nov;
29(1):119-123.
PMID: 36347134
Introduction: Patient positioning may impact diagnostic quality when obtaining radiographs of the musculoskeletal (MSK) system. Hence, knowledge on patient positioning, as seen in the radiograph, followed by informed adjusted retake...
5.
Williams-Noonan B, Speer M, Le T, Sadek M, Thompson P, Norton R, et al.
J Chem Inf Model
. 2022 Sep;
62(19):4605-4619.
PMID: 36178379
The ability to predict cell-permeable candidate molecules has great potential to assist drug discovery projects. Large molecules that lie beyond the Rule of Five (bRo5) are increasingly important as drug...
6.
Kaiserman D, Zhao P, Rowe C, Leong A, Barlow N, Joeckel L, et al.
PLoS One
. 2022 Jul;
17(7):e0270584.
PMID: 35881628
Granzyme K (GzmK) is a tryptic member of the granzyme family of chymotrypsin-like serine proteases produced by cells of the immune system. Previous studies have indicated that GzmK activates protease-activated...
7.
Rahman A, Matthews M, Nowell C, Chalmers D, Thompson P, Nicholson S, et al.
Bioorg Chem
. 2022 Apr;
123:105763.
PMID: 35366581
The SPRY domain-containing SOCS box protein-2 (SPSB2) plays a critical role in the degradation of inducible nitric oxide synthase (iNOS) in macrophages. In this study, we have conjugated a peptide...
8.
Barlow N, Vanga S, Savmarker J, Sandstrom A, Burns P, Hallberg A, et al.
RSC Med Chem
. 2021 Jan;
11(2):234-244.
PMID: 33479630
Macrocyclic analogues of the linear hexapeptide, angiotensin IV (AngIV) have proved to be potent inhibitors of insulin-regulated aminopeptidase (IRAP, oxytocinase, EC 3.4.11.3). Along with higher affinity, macrocycles may also offer...
9.
Babu Reddiar S, Al-Wassiti H, Pouton C, Nowell C, Matthews M, Rahman A, et al.
Bioorg Med Chem
. 2020 Dec;
29:115906.
PMID: 33310547
Inhibitors of protein-protein interactions can be developed through a number of technologies to provide leads that include cell-impermeable molecules. Redesign of these impermeable leads to provide cell-permeable derivatives can be...
10.
Barlow N, Thompson P
Front Pharmacol
. 2020 Oct;
11:585930.
PMID: 33101040
The insulin regulated aminopeptidase (IRAP) has been proposed as an important therapeutic target for indications including Alzheimer's disease and immune disorders. To date, a number of IRAP inhibitor designs have...