IRAP Inhibitors: M1-Aminopeptidase Family Inspiration

Overview

Journal Front Pharmacol

Date 2020 Oct 26

PMID 33101040

Citations 6

Authors

Nicholas Barlow

Philip E Thompson

Affiliations

Soon will be listed here.

Abstract

The insulin regulated aminopeptidase (IRAP) has been proposed as an important therapeutic target for indications including Alzheimer's disease and immune disorders. To date, a number of IRAP inhibitor designs have been investigated but the total number of molecules investigated remains quite small. As a member the M1 aminopeptidase family, IRAP shares numerous structural features with the other M1 aminopeptidases. The study of those enzymes and the development of inhibitors provide key learnings and new approaches and are potential sources of inspiration for future IRAP inhibitors.

Citing Articles

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ERAP Inhibitors in Autoimmunity and Immuno-Oncology: Medicinal Chemistry Insights.

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The Discovery of New Inhibitors of Insulin-Regulated Aminopeptidase by a High-Throughput Screening of 400,000 Drug-like Compounds.

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Hydrogen Peroxide Induced Toxicity Is Reversed by the Macrocyclic IRAP-Inhibitor HA08 in Primary Hippocampal Cell Cultures.

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Discovery of Selective Inhibitor Leads by Targeting an Allosteric Site in Insulin-Regulated Aminopeptidase.

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