Ngak Leng Sim
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Explore the profile of Ngak Leng Sim including associated specialties, affiliations and a list of published articles.
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4
Citations
16
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Recent Articles
1.
Zhu G, Rahman C, Getty V, Odinokov D, Baruah P, Carrie H, et al.
Nat Biomed Eng
. 2025 Mar;
PMID: 40055581
The quantification of circulating tumour DNA (ctDNA) in blood enables non-invasive surveillance of cancer progression. Here we show that a deep-learning model can accurately quantify ctDNA from the density distribution...
2.
Huang C, Jiang N, Shen M, Lai G, Tan A, Jain A, et al.
Cancer Res
. 2024 Apr;
84(12):2009-2020.
PMID: 38587551
Significance: Non-small cell lung cancers driven by nonsmoking-related oncogenes do not harbor genomic scars caused by smoking regardless of smoking history, indicating that the impact of smoking on these tumors...
3.
A Randomized Phase 2 Trial of Nivolumab Versus Nivolumab-Ipilimumab Combination in EGFR-Mutant NSCLC
Lai G, Yeo J, Jain A, Zhou S, Pang M, Alvarez J, et al.
JTO Clin Res Rep
. 2022 Nov;
3(12):100416.
PMID: 36426287
Introduction: Although immune checkpoint inhibitors (ICIs) have dramatically improved outcomes for nononcogene-addicted NSCLC, monotherapy with programmed cell death protein-1 (PD1) inhibition has been associated with low efficacy in the EGFR-mutant...
4.
Huang W, Sim N, Skanderup A
Methods Mol Biol
. 2022 Jun;
2493:53-66.
PMID: 35751808
Accurate identification of somatic mutations is crucial for discovery and identification of driver mutations in cancer tumors. Here, we describe the updated Somatic Mutation calling method using a Random Forest...
5.
Sheng T, Ho S, Ooi W, Xu C, Xing M, Padmanabhan N, et al.
Genome Med
. 2021 Oct;
13(1):158.
PMID: 34635154
Background: Enhancers are distal cis-regulatory elements required for cell-specific gene expression and cell fate determination. In cancer, enhancer variation has been proposed as a major cause of inter-patient heterogeneity-however, most...