Anders Jacobsen Skanderup
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Explore the profile of Anders Jacobsen Skanderup including associated specialties, affiliations and a list of published articles.
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27
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789
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Recent Articles
1.
Zhu G, Rahman C, Getty V, Odinokov D, Baruah P, Carrie H, et al.
Nat Biomed Eng
. 2025 Mar;
PMID: 40055581
The quantification of circulating tumour DNA (ctDNA) in blood enables non-invasive surveillance of cancer progression. Here we show that a deep-learning model can accurately quantify ctDNA from the density distribution...
2.
Lee Y, Phua C, Yuan J, Zhang B, Lee M, Kannan S, et al.
Genome Med
. 2024 Jul;
16(1):91.
PMID: 39034402
Background: The identification of cancer driver genes from sequencing data has been crucial in deepening our understanding of tumor biology and expanding targeted therapy options. However, apart from the most...
3.
Chen J, Kaya N, Zhang Y, Kendarsari R, Sekar K, Lee Chong S, et al.
J Hepatol
. 2024 May;
81(4):667-678.
PMID: 38782118
Background & Aims: Hepatocellular carcinoma (HCC) is a highly fatal cancer characterized by high intra-tumor heterogeneity (ITH). A panoramic understanding of its tumor evolution, in relation to its clinical trajectory,...
4.
Revkov E, Kulshrestha T, Sung K, Skanderup A
Commun Biol
. 2023 Apr;
6(1):394.
PMID: 37041233
Tumors are complex masses composed of malignant and non-malignant cells. Variation in tumor purity (proportion of cancer cells in a sample) can both confound integrative analysis and enable studies of...
5.
Xu C, Huang K, Law J, Chua J, Sheng T, Flores N, et al.
Gut
. 2023 Mar;
72(9):1651-1663.
PMID: 36918265
Objective: Gastric cancer (GC) is a leading cause of cancer mortality, with being the second most frequently mutated driver gene in GC. We sought to decipher -specific GC regulatory networks...
6.
Skanderup A, Ang S, Tan D
Clin Cancer Res
. 2023 Feb;
29(8):1381-1383.
PMID: 36757332
Precision oncology is predicated on optimal molecular profiling that is "fit for purpose" to identify therapeutic vulnerabilities. Liquid biopsies may compensate for inadequate genotyping, but remain less sensitive and specific...
7.
Krishnamachari K, Lu D, Swift-Scott A, Yeraliyev A, Lee K, Huang W, et al.
Nat Commun
. 2022 Jul;
13(1):4248.
PMID: 35869060
Identification of somatic mutations in tumor samples is commonly based on statistical methods in combination with heuristic filters. Here we develop VarNet, an end-to-end deep learning approach for identification of...
8.
Ho S, Sheng T, Xing M, Ooi W, Xu C, Sundar R, et al.
Gut
. 2022 Jul;
72(2):226-241.
PMID: 35817555
Objective: Gastric cancer (GC) comprises multiple molecular subtypes. Recent studies have highlighted mesenchymal-subtype GC (Mes-GC) as a clinically aggressive subtype with few treatment options. Combining multiple studies, we derived and...
9.
Joanito I, Wirapati P, Zhao N, Nawaz Z, Yeo G, Lee F, et al.
Nat Genet
. 2022 Jun;
54(7):963-975.
PMID: 35773407
The consensus molecular subtype (CMS) classification of colorectal cancer is based on bulk transcriptomics. The underlying epithelial cell diversity remains unclear. We analyzed 373,058 single-cell transcriptomes from 63 patients, focusing...
10.
Rohatgi N, Ghoshdastider U, Baruah P, Kulshrestha T, Skanderup A
Cell Rep
. 2022 May;
39(6):110800.
PMID: 35545044
Tumors are heterogeneous cellular environments with entwined metabolic dependencies. Here, we use a tumor transcriptome deconvolution approach to profile the metabolic states of cancer and non-cancer (stromal) cells in bulk...