Neil V Marrion
Overview
Explore the profile of Neil V Marrion including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
40
Citations
2557
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Butler A, Ascione R, Marrion N, Harmer S, Hancox J
Sci Rep
. 2024 Feb;
14(1):3185.
PMID: 38326449
Human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) represent an in vitro model of cardiac function. Isolated iPSC-CMs, however, exhibit electrophysiological heterogeneity which hinders their utility in the study of certain...
2.
Charlick J, Bozadzhieva D, Butler A, Wilkinson K, Marrion N
Eur J Neurosci
. 2023 Nov;
59(1):3-16.
PMID: 38018635
The expression of IKCa (SK4) channel subunits overlaps with that of SK channel subunits, and it has been proposed that the two related subunits prefer to co-assemble to form heteromeric...
3.
van Herck I, Seutin V, Bentzen B, Marrion N, Edwards A
Biophys J
. 2023 Feb;
122(7):1143-1157.
PMID: 36760125
Small-conductance (SK) calcium-activated potassium channels are a promising treatment target in atrial fibrillation. However, the functional properties that differentiate SK inhibitors remain poorly understood. The objective of this study was...
4.
Butler A, Hancox J, Marrion N
J Biol Chem
. 2022 Dec;
299(1):102783.
PMID: 36502918
Three isoforms of small conductance, calcium-activated potassium (SK) channel subunits have been identified (SK1-3) that exhibit a broad and overlapping tissue distribution. SK channels have been implicated in several disease...
5.
Stan G, Church T, Randall E, Harvey J, Brown J, Wilkinson K, et al.
Sci Rep
. 2022 Sep;
12(1):15231.
PMID: 36075936
Accumulation of tau is observed in dementia, with human tau displaying 6 isoforms grouped by whether they display either 3 or 4 C-terminal repeat domains (3R or 4R) and exhibit...
6.
Wilson S, Dempsey C, Hancox J, Marrion N
Sci Rep
. 2019 Dec;
9(1):19825.
PMID: 31882846
The hERG potassium channel influences ventricular action potential duration. Extracellular acidosis occurs in pathological states including cardiac ischaemia. It reduces the amplitude of hERG current and speeds up deactivation, which...
7.
Higham J, Sahu G, Wazen R, Colarusso P, Gregorie A, Harvey B, et al.
Mol Pharmacol
. 2019 May;
96(1):115-126.
PMID: 31048549
Three small conductance calcium-activated potassium channel (SK) subunits have been cloned and found to preferentially form heteromeric channels when expressed in a heterologous expression system. The original cloning of the...
8.
Shamsaldeen Y, Culliford L, Clout M, James A, Ascione R, Hancox J, et al.
Biochem Biophys Res Commun
. 2019 Mar;
512(4):684-690.
PMID: 30922569
Inhibition of SK channel function is being pursued in animal models as a possible therapeutic approach to treat atrial fibrillation (AF). However, the pharmacology of SK channels in human atria...
9.
Church T, Brown J, Marrion N
J Neurophysiol
. 2019 Jan;
121(3):773-784.
PMID: 30625002
Action potential firing in hippocampal pyramidal neurons is regulated by generation of an afterhyperpolarization (AHP). Three phases of AHP are recognized, with the fast AHP regulating action potential firing at...
10.
Alexander S, Christopoulos A, Davenport A, Kelly E, Marrion N, Peters J, et al.
Br J Pharmacol
. 2017 Oct;
174 Suppl 1:S17-S129.
PMID: 29055040
The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to...