Neil D Rawlings
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Explore the profile of Neil D Rawlings including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Rawlings N, Bateman A
Protein Sci
. 2020 Sep;
30(1):83-92.
PMID: 32920969
The MEROPS website (https://www.ebi.ac.uk/merops) and database was established in 1996 to present the classification and nomenclature of proteolytic enzymes. This was expanded to include a classification of protein inhibitors of...
2.
Barrett A, Rawlings N
Perspect Drug Discov Des
. 2020 Apr;
6(1):1-11.
PMID: 32288275
The known cysteine peptidases have been classified into 35 sequence families. We argue that these have arisen from at least five separate evolutionary origins, each of which is represented by...
3.
Rawlings N
Biochim Biophys Acta Proteins Proteom
. 2019 Dec;
1868(2):140345.
PMID: 31838087
Proteolytic enzymes and their homologues have been classified into clans by comparing the tertiary structures of the peptidase domains, into families by comparing the protein sequences of the peptidase domains,...
4.
Rawlings N, Bateman A
Biochimie
. 2019 Aug;
166:4-18.
PMID: 31377195
The distribution of all peptidase homologues across all phyla of organisms was analysed to determine within which kingdom each of the 271 families originated. No family was found to be...
5.
Mitchell A, Attwood T, Babbitt P, Blum M, Bork P, Bridge A, et al.
Nucleic Acids Res
. 2018 Nov;
47(D1):D351-D360.
PMID: 30398656
The InterPro database (http://www.ebi.ac.uk/interpro/) classifies protein sequences into families and predicts the presence of functionally important domains and sites. Here, we report recent developments with InterPro (version 70.0) and its...
6.
Richardson L, Rawlings N, Salazar G, Almeida A, Haft D, Ducq G, et al.
Nucleic Acids Res
. 2018 Oct;
47(D1):D564-D572.
PMID: 30364992
Automatic annotation of protein function is routinely applied to newly sequenced genomes. While this provides a fine-grained view of an organism's functional protein repertoire, proteins, more commonly function in a...
7.
Li F, Wang Y, Li C, Marquez-Lago T, Leier A, Rawlings N, et al.
Brief Bioinform
. 2018 Sep;
20(6):2150-2166.
PMID: 30184176
The roles of proteolytic cleavage have been intensively investigated and discussed during the past two decades. This irreversible chemical process has been frequently reported to influence a number of crucial...
8.
Song J, Wang Y, Li F, Akutsu T, Rawlings N, Webb G, et al.
Brief Bioinform
. 2018 Jun;
20(2):638-658.
PMID: 29897410
Regulation of proteolysis plays a critical role in a myriad of important cellular processes. The key to better understanding the mechanisms that control this process is to identify the specific...
9.
Rawlings N, Barrett A, Thomas P, Huang X, Bateman A, Finn R
Nucleic Acids Res
. 2017 Nov;
46(D1):D624-D632.
PMID: 29145643
The MEROPS database (http://www.ebi.ac.uk/merops/) is an integrated source of information about peptidases, their substrates and inhibitors. The hierarchical classification is: protein-species, family, clan, with an identifier at each level. The...
10.
Rawlings N
Methods Mol Biol
. 2017 May;
1594:213-226.
PMID: 28456986
This chapter describes how to retrieve data on lysosomal peptidases from the MEROPS database for proteolytic enzymes, their substrates and inhibitors ( http://merops.sanger.ac.uk ). Features described in this chapter include...