Neil A Hukriede
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Explore the profile of Neil A Hukriede including associated specialties, affiliations and a list of published articles.
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61
Citations
1371
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Recent Articles
1.
Shapiro O, Woods C, Gleixner A, Sannino S, Ngo M, McDaniels M, et al.
Anal Biochem
. 2024 Nov;
697:115712.
PMID: 39522672
Hsp70 prevents protein aggregation and is cytoprotective, but sustained Hsp70 overexpression is problematic. Therefore, we characterized small molecule agonists that augment Hsp70 activity. Because cumbersome assays were required to assay...
2.
Maggiore J, LeGraw R, Przepiorski A, Velazquez J, Chaney C, Vanichapol T, et al.
Kidney Int
. 2024 Jun;
106(6):1086-1100.
PMID: 38901605
Vascularization plays a critical role in organ maturation and cell-type development. Drug discovery, organ mimicry, and ultimately transplantation hinge on achieving robust vascularization of in vitro engineered organs. Here, focusing...
3.
Pereira B, Zeng Y, Maggiore J, Schweickart R, Eng D, Kaverina N, et al.
Am J Physiol Renal Physiol
. 2023 Oct;
326(1):F120-F134.
PMID: 37855038
As life expectancy continues to rise, age-related diseases are becoming more prevalent. For example, proteinuric glomerular diseases typified by podocyte injury have worse outcomes in the elderly compared with young...
4.
Cervino A, Collodel M, Lopez I, Roa C, Hochbaum D, Hukriede N, et al.
Sci Rep
. 2023 Oct;
13(1):16671.
PMID: 37794075
The nephron, functional unit of the vertebrate kidney, is specialized in metabolic wastes excretion and body fluids osmoregulation. Given the high evolutionary conservation of gene expression and segmentation patterning between...
5.
Kaverina N, Schweickart R, Chan G, Maggiore J, Eng D, Zeng Y, et al.
Aging (Albany NY)
. 2023 Jul;
15(14):6658-6689.
PMID: 37487005
The decrease in the podocyte's lifespan and health-span that typify healthy kidney aging cause a decrease in their normal structure, physiology and function. The ability to halt and even reverse...
6.
Sander V, Przepiorski A, Hukriede N, Davidson A
Methods Mol Biol
. 2023 Jul;
2664:69-83.
PMID: 37423983
Kidney organoids differentiated from human pluripotent stem cells (hPSC) have advanced the study of kidney diseases by providing an in vitro system that outperforms traditional monolayer cell culture and complements...
7.
Maggiore J, LeGraw R, Przepiorski A, Velazquez J, Chaney C, Streeter E, et al.
bioRxiv
. 2023 Jun;
PMID: 37333155
Vascularization plays a critical role in organ maturation and cell type development. Drug discovery, organ mimicry, and ultimately transplantation in a clinical setting thereby hinges on achieving robust vascularization of...
8.
Cervino A, Collodel M, Lopez I, Hochbaum D, Hukriede N, Cirio M
bioRxiv
. 2023 Apr;
PMID: 37090653
The nephron, functional unit of the vertebrate kidney, is specialized in metabolic wastes excretion and body fluids osmoregulation. Given the high evolutionary conservation of gene expression and segmentation patterning between...
9.
Montalbetti N, Przepiorski A, Shi S, Sheng S, Baty C, Maggiore J, et al.
Am J Physiol Renal Physiol
. 2022 Aug;
323(4):F479-F491.
PMID: 35979965
Kidney organoids derived from human or rodent pluripotent stem cells have glomerular structures and differentiated/polarized nephron segments. Although there is an increasing understanding of the patterns of expression of transcripts...
10.
Long K, Vaughn Z, McDaniels M, Joyasawal S, Przepiorski A, Parasky E, et al.
ACS Pharmacol Transl Sci
. 2022 Apr;
5(4):207-215.
PMID: 35434532
Acute kidney injury (AKI), a sudden loss of kidney function, is a common and serious condition for which there are no approved specific therapies. While there are multiple approaches to...