Neetu Dayal
Overview
Explore the profile of Neetu Dayal including associated specialties, affiliations and a list of published articles.
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26
Citations
109
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Recent Articles
11.
Dayal N, Onyedibe K, Gribble W, Sintim H
Eur J Med Chem
. 2022 Jul;
240:114550.
PMID: 35793578
The National Institute of Health (NIH) estimates that the majority of human microbial infections are either linked to or directly caused by bacterial biofilms and these infections are immune to...
12.
Onyedibe K, Dayal N, Sintim H
RSC Med Chem
. 2021 Nov;
12(11):1879-1893.
PMID: 34825185
Bacteria persister cells are immune to most antibiotics and hence compounds that are active against persister bacteria are needed. We screened a chemical library of SF- and SCF-substituted tetrahydroquinoline compounds,...
13.
Dayal N, Reznickova E, Hernandez D, Perina M, Torregrosa-Allen S, Elzey B, et al.
J Med Chem
. 2021 Jul;
64(15):10981-10996.
PMID: 34288692
The 3-pyrazolo[4,3-]quinoline moiety has been recently shown to be a privileged kinase inhibitor core with potent activities against acute myeloid leukemia (AML) cell lines in vitro. Herein, various 3-pyrazolo[4,3-]quinoline-containing compounds...
14.
Dayal N, Wang M, Sintim H
ACS Omega
. 2020 Sep;
5(37):23799-23807.
PMID: 32984700
Multicomponent reaction (MCR) is often used to rapidly assemble complex compounds for drug screening. Povarov MCR has been used to prepare a new library containing tetrahydro-3-pyrazolo[4,3-]quinoline core and the library...
15.
Inhibitors of Intracellular Gram-Positive Bacterial Growth Synthesized via Povarov-Doebner Reactions
Dayal N, Opoku-Temeng C, Mohammad H, Abutaleb N, Hernandez D, Onyedibe K, et al.
ACS Infect Dis
. 2019 Sep;
5(11):1820-1830.
PMID: 31512848
can survive both inside and outside of phagocytic and nonphagocytic host cells. Once in the intracellular milieu, most antibiotics have reduced ability to kill , thus resulting in relapse of...
16.
Dayal N, Mikek C, Hernandez D, Naclerio G, Chu E, Carter-Cooper B, et al.
Eur J Med Chem
. 2019 Jul;
180:449-456.
PMID: 31330446
Rho-associated protein kinases (ROCKs) are ubiquitously expressed in most adult tissues, and are involved in modulating the cytoskeleton, protein synthesis and degradation pathways, synaptic function, and autophagy to list a...
17.
Mikek C, West S, Gwin J, Dayal N, Sintim H, Lewis E
ACS Omega
. 2018 Oct;
3(9):11582-11591.
PMID: 30320266
Diminazene, DMZ, (or berenil) has been reported as a tight binder of G-quadruplexes. G-Quadruplex structures are often located in the promotor regions of oncogenes and may play a regulatory role...
18.
Opoku-Temeng C, Naclerio G, Mohammad H, Dayal N, Abutaleb N, Seleem M, et al.
Eur J Med Chem
. 2018 Jun;
155:797-805.
PMID: 29957525
Various reports of multidrug-resistant bacteria that are immune to all available FDA-approved drugs demand the development of novel chemical scaffolds as antibiotics. From screening a chemical library, we identified compounds...
19.
Opoku-Temeng C, Dayal N, Sooreshjani M, Sintim H
Bioorg Chem
. 2018 Apr;
78:418-426.
PMID: 29698892
Histone modification, a post-translational modification of histones and involving various covalent tags, such as methyl, phosphate and acetate groups, affects gene expression and hence modulates various cellular events, including growth...
20.
Opoku-Temeng C, Dayal N, Hernandez D, Naganna N, Sintim H
Chem Commun (Camb)
. 2018 Apr;
54(36):4521-4524.
PMID: 29629444
Cyclin-dependent kinases have emerged as important targets for cancer therapy. HSD992, containing a novel scaffold based on the tetrahydro-3H-pyrazolo[4,3-a]phenanthridine core, inhibits CDK2/3 but not other CDKs and also potently inhibits...