Kenneth I Onyedibe
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Explore the profile of Kenneth I Onyedibe including associated specialties, affiliations and a list of published articles.
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20
Citations
172
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Recent Articles
1.
Elmanfi S, Onyedibe K, Aryal U, Kononen E, Sintim H, Gursoy U
J Oral Microbiol
. 2024 Dec;
17(1):2431453.
PMID: 39669221
Background: Bacterial cyclic dinucleotides (CDNs), cyclic di-guanosine monophosphate (c-di-GMP), and cyclic di-adenosine monophosphate (c-di-AMP) upregulate interferon signaling proteins of human gingival fibroblasts (HGFs). However, the simultaneous effect of bacterial CDNs...
2.
Onyedibe K, Mohallem R, Wang M, Aryal U, Sintim H
J Proteomics
. 2023 Mar;
279:104869.
PMID: 36889538
Cyclic dinucleotides (CDNs), such as 2'3'-cGAMP, bind to STING to trigger the production of cytokines and interferons, mainly via activation of TBK1. STING activation by CDN also leads to the...
3.
Onyedibe K, Nemeth A, Dayal N, Smith R, Lamptey J, Ernst R, et al.
ACS Infect Dis
. 2023 Jan;
9(2):283-295.
PMID: 36651182
Colistin, typically viewed as the antibiotic of last resort to treat infections caused by multidrug-resistant (MDR) Gram-negative bacteria, had fallen out of favor due to toxicity issues. The recent increase...
4.
Karanja C, Naganna N, Abutaleb N, Dayal N, Onyedibe K, Aryal U, et al.
Molecules
. 2022 Aug;
27(16).
PMID: 36014324
A new class of alkynyl isoquinoline antibacterial compounds, synthesized via Sonogashira coupling, with strong bactericidal activity against a plethora of Gram-positive bacteria including methicillin- and vancomycin-resistant strains is presented. HSN584...
5.
Dayal N, Onyedibe K, Gribble W, Sintim H
Eur J Med Chem
. 2022 Jul;
240:114550.
PMID: 35793578
The National Institute of Health (NIH) estimates that the majority of human microbial infections are either linked to or directly caused by bacterial biofilms and these infections are immune to...
6.
Naclerio G, Abutaleb N, Onyedibe K, Karanja C, Eldesouky H, Liang H, et al.
J Med Chem
. 2022 Apr;
65(9):6612-6630.
PMID: 35482444
Methicillin-resistant (MRSA) infections are still difficult to treat, despite the availability of many FDA-approved antibiotics. Thus, new compound scaffolds are still needed to treat MRSA. The oxadiazole-containing compound, , has...
7.
Naclerio G, Onyedibe K, Karanja C, Aryal U, Sintim H
ACS Infect Dis
. 2022 Mar;
8(4):865-877.
PMID: 35297603
Drug-resistant bacterial pathogens still cause high levels of mortality annually despite the availability of many antibiotics. Methicillin-resistant (MRSA) is especially problematic, and the rise in resistance to front-line treatments like...
8.
Onyedibe K, Elmanfi S, Aryal U, Kononen E, Gursoy U, Sintim H
J Oral Microbiol
. 2022 Jan;
14(1):2003617.
PMID: 34992733
Background: Constant exposure of human gingival fibroblasts (HGFs) to oral pathogens trigger selective immune responses. Recently, the activation of immune response to cyclic dinucleotides (CDNs) via STING has come to...
9.
Onyedibe K, Dayal N, Sintim H
RSC Med Chem
. 2021 Nov;
12(11):1879-1893.
PMID: 34825185
Bacteria persister cells are immune to most antibiotics and hence compounds that are active against persister bacteria are needed. We screened a chemical library of SF- and SCF-substituted tetrahydroquinoline compounds,...
10.
Naclerio G, Abutaleb N, Onyedibe K, Seleem M, Sintim H
RSC Med Chem
. 2021 Jan;
11(1):102-110.
PMID: 33479609
According to the Centers for Disease Control and Prevention (CDC), methicillin-resistant (MRSA) affects about 80 000 patients in the US annually and directly causes about 11 000 deaths. Therefore, despite...