Nawal A El-Koussi
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Explore the profile of Nawal A El-Koussi including associated specialties, affiliations and a list of published articles.
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13
Citations
71
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Recent Articles
1.
Wagih N, Abdel-Rahman I, El-Koussi N, Abuo-Rahma G
RSC Adv
. 2025 Jan;
15(2):966-1010.
PMID: 39807197
Cancer is one of the leading causes of morbidity and mortality worldwide. One of the primary causes of cancer development and progression is epigenetic dysregulation, which is a heritable modification...
2.
Al-Wahaibi L, Elshamsy A, Ali T, Youssif B, Brase S, Abdel-Aziz M, et al.
ACS Omega
. 2024 Aug;
9(32):34358-34369.
PMID: 39157105
We developed and synthesized tetrahydropyrimidine derivatives as possible cytotoxic agents to inhibit EGFR and VEGFR-2 in the present study. Our study completely assesses the cytotoxic efficiency of pyrimidine-based derivatives against...
3.
Al-Wahaibi L, Elshamsy A, Ali T, Youssif B, Brase S, Abdel-Aziz M, et al.
Front Chem
. 2024 May;
12:1387923.
PMID: 38800576
A novel series of dihydropyrimidine/sulphonamide hybrids with anti-inflammatory properties have been developed and tested as dual mPGES-1/5-LOX inhibitors. assay, results showed that compounds , , , and were the most...
4.
Abdel-Aziz S, Taher E, Lan P, El-Koussi N, Salem O, Gomaa H, et al.
Arch Pharm (Weinheim)
. 2022 Apr;
355(7):e2200024.
PMID: 35429006
Some cyclooxygenase (COX)-2 selective medications were withdrawn from the market just a few years after their production due to cardiovascular side effects. In this study, a new series of pyrimidine/thiazole...
5.
Hofny H, Mohamed M, Gomaa H, Abdel-Aziz S, Youssif B, El-Koussi N, et al.
Bioorg Chem
. 2021 Apr;
112:104920.
PMID: 33910078
DNA gyrase and topoisomerase IV (topo IV) inhibitors are among the most interesting antibacterial drug classes without antibacterial pipeline representative. Twenty-four new quinoline-1,3,4-oxadiazole and quinoline-1,2,4-triazole hybrids were developed and tested...
6.
Abdel-Aziz S, Taher E, Lan P, Asaad G, Gomaa H, El-Koussi N, et al.
Bioorg Chem
. 2021 Apr;
111:104890.
PMID: 33872924
A new series of pyrimidine-5-carbonitrile derivatives 8a-p carrying the 1,3-thiazole moiety has been designed and synthesized as novel anti-inflammatory EGFR inhibitors with cardiac and gastric safety profiles. 8a-p have been...
7.
Mohamed Z, El-Koussi N, Mahfouz N, Youssef A, Abdel Jaleel G, Shouman S
Eur J Med Chem
. 2015 May;
97:75-82.
PMID: 25942354
The progestational potency and selectivity of synthetic steroidal agonists can be enhanced by even larger chemical moieties at 17α-position of the steroid backbones. Hereby a series 5a-c and 6a-c of...
8.
Abdel-Rahman H, El-Koussi N, Hassan H
Arch Pharm (Weinheim)
. 2009 Jan;
342(2):94-9.
PMID: 19173243
A series of fluorinated 1,2,4-triazolo[1,5-a]pyrimidine-6-carboxylic acid derivatives was designed and synthesized as fluoroquinolone analogues. The synthesized compounds were screened against Mycobacterium tuberculosis H(37)R(v) strain at 6.25 microg/mL concentration. Compound 4,...
9.
Abdel-Hamid M, Abdel-Hafez A, El-Koussi N, Mahfouz N
J Enzyme Inhib Med Chem
. 2008 Aug;
24(3):722-9.
PMID: 18720193
A linear quantitative structure-activity relationship (QSAR) study that encodes various aspects of physicochemical, topological and electronic descriptors has been developed for a series of 1,3,4-thiadiazole-2-thione derivatives (1a-r and 2a-c). The...
10.
Abdel-Hamid M, Abdel-Hafez A, El-Koussi N, Mahfouz N, Innocenti A, Supuran C
Bioorg Med Chem
. 2007 Sep;
15(22):6975-84.
PMID: 17822907
A new series of 1,3,4-thiadiazole-2-thione derivatives have been prepared and assayed for the inhibition of three physiologically relevant carbonic anhydrase (CA, EC 4.2.1.1) isozymes, the cytosolic human isozymes I and...