Navratna Vajpai
Overview
Explore the profile of Navratna Vajpai including associated specialties, affiliations and a list of published articles.
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18
Citations
544
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Recent Articles
1.
Reddy V C, Srivatsa K, Vajpai N, R G, Upadhya A, Srivastava A, et al.
Protein Expr Purif
. 2025 Jan;
229:106665.
PMID: 39875009
No abstract available.
2.
Pujahari S, Purusottam R, Mali P, Sarkar S, Khaneja N, Vajpai N, et al.
Anal Chem
. 2024 Feb;
96(12):4756-4763.
PMID: 38326990
The integrity of a higher order structure (HOS) is an essential requirement to ensure the efficacy, stability, and safety of protein therapeutics. Solution-state nuclear magnetic resonance (NMR) occupies a unique...
3.
Dey A, Mitra D, Rachineni K, Khatri L, Paithankar H, Vajpai N, et al.
Chembiochem
. 2022 Oct;
23(23):e202200489.
PMID: 36227643
The current trend in the biopharmaceutical market has boosted the development and production of biological drugs with high efficacy and fidelity for receptor binding. While high-resolution structural insights into binding...
4.
Goyal P, Pai H, Kodali P, Vats B, Vajpai N, Annegowda S, et al.
PLoS One
. 2021 Jun;
16(6):e0253168.
PMID: 34133466
Insulin glargine is a long-acting analogue of human insulin that has been used to manage hyperglycemia in patients with diabetes mellitus (DM) for nearly 20 years. Insulin glargine has a...
5.
Srivatsa K, Gokhale Y, Chakrabarti P, Kulshrestha A, Vajpai N
J Pharm Biomed Anal
. 2021 Jun;
203:114188.
PMID: 34126389
High molecular weight protein aggregates present in a recombinant human insulin and analogs are conventionally quantified by SEC-HPLC and identified by SEC-MALS as oligomeric population which lacks precise identification of...
6.
Shukla V, Srivatsa K, Madhu Kumar M, Vajpai N, Agarwal N, Nethra S, et al.
Protein Expr Purif
. 2021 May;
185:105895.
PMID: 33957255
Biopharmaceutical development demands appropriate understanding of product related variants, which are formed due to post-translational modification and during downstream processing. These variants can lead to low yield, reduced biological activity,...
7.
Vo U, Vajpai N, Embrey K, Golovanov A
Sci Rep
. 2016 Jul;
6:29706.
PMID: 27412770
The cycling between GDP- and GTP- bound forms of the Ras protein is partly regulated by the binding of Sos. The structural/dynamic behavior of the complex formed between activated Sos...
8.
Vo U, Vajpai N, Flavell L, Bobby R, Breeze A, Embrey K, et al.
J Biol Chem
. 2015 Nov;
291(4):1703-1718.
PMID: 26565026
The activity of Ras is controlled by the interconversion between GTP- and GDP-bound forms partly regulated by the binding of the guanine nucleotide exchange factor Son of Sevenless (Sos). The...
9.
Structural and dynamic insights into the energetics of activation loop rearrangement in FGFR1 kinase
Klein T, Vajpai N, Phillips J, Davies G, Holdgate G, Phillips C, et al.
Nat Commun
. 2015 Jul;
6:7877.
PMID: 26203596
Protein tyrosine kinases differ widely in their propensity to undergo rearrangements of the N-terminal Asp-Phe-Gly (DFG) motif of the activation loop, with some, including FGFR1 kinase, appearing refractory to this...
10.
Nielsen G, Jonker H, Vajpai N, Grzesiek S, Schwalbe H
Chembiochem
. 2013 Jul;
14(14):1799-806.
PMID: 23843149
Protein kinases are highly dynamic and complex molecules. Here we present high-pressure and relaxation studies of the activated p38α mitogen-activated protein kinase (MAPK). p38α plays a central role in inflammatory...