Navratna Vajpai
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Explore the profile of Navratna Vajpai including associated specialties, affiliations and a list of published articles.
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18
Citations
544
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Recent Articles
11.
Vajpai N, Schott A, Vogtherr M, Breeze A
Biomol NMR Assign
. 2013 Jan;
8(1):85-8.
PMID: 23325512
Members of the fibroblast growth factor receptor tyrosine kinase family (FGFR1-4) play an important role in many signalling cascades. Although tightly regulated, aberrant activity of these enzymes may lead to,...
12.
Vajpai N, Nisius L, Wiktor M, Grzesiek S
Proc Natl Acad Sci U S A
. 2013 Jan;
110(5):E368-76.
PMID: 23284170
Proteins denature not only at high, but also at low temperature as well as high pressure. These denatured states are not easily accessible for experiment, because usually heat denaturation causes...
13.
Huang J, Gentner M, Vajpai N, Grzesiek S, Blackledge M
Biochem Soc Trans
. 2012 Sep;
40(5):989-94.
PMID: 22988852
Many functional proteins do not have well defined folded structures. In recent years, both experimental and computational approaches have been developed to study the conformational behaviour of this type of...
14.
Klammt C, Maslennikov I, Bayrhuber M, Eichmann C, Vajpai N, Chiu E, et al.
Nat Methods
. 2012 May;
9(8):834-9.
PMID: 22609626
Although nearly half of today's major pharmaceutical drugs target human integral membrane proteins (hIMPs), only 30 hIMP structures are currently available in the Protein Data Bank, largely owing to inefficiencies...
15.
Vajpai N, Gentner M, Huang J, Blackledge M, Grzesiek S
J Am Chem Soc
. 2010 Feb;
132(9):3196-203.
PMID: 20155903
Current NMR information on side-chain conformations of unfolded protein states is sparse due to the poor dispersion particularly of side-chain proton resonances. We present here optimized schemes for the detection...
16.
Zhang J, Adrian F, Jahnke W, Cowan-Jacob S, Li A, Iacob R, et al.
Nature
. 2010 Jan;
463(7280):501-6.
PMID: 20072125
In an effort to find new pharmacological modalities to overcome resistance to ATP-binding-site inhibitors of Bcr-Abl, we recently reported the discovery of GNF-2, a selective allosteric Bcr-Abl inhibitor. Here, using...
17.
Vajpai N, Strauss A, Fendrich G, Cowan-Jacob S, Manley P, Jahnke W, et al.
Biomol NMR Assign
. 2009 Jul;
2(1):41-2.
PMID: 19636920
Imatinib (Glivec or Gleevec) potently inhibits the tyrosine kinase activity of BCR-ABL, a constitutively activated kinase, which causes chronic myelogenous leukemia (CML). Here we report the first almost complete backbone...
18.
Vajpai N, Strauss A, Fendrich G, Cowan-Jacob S, Manley P, Grzesiek S, et al.
J Biol Chem
. 2008 Apr;
283(26):18292-302.
PMID: 18434310
Current structural understanding of kinases is largely based on x-ray crystallographic studies, whereas very little data exist on the conformations and dynamics that kinases adopt in the solution state. ABL...
19.
Dames S, Aregger R, Vajpai N, Bernado P, Blackledge M, Grzesiek S
J Am Chem Soc
. 2006 Oct;
128(41):13508-14.
PMID: 17031964
Residual dipolar couplings (RDCs) observed by NMR in solution under weak alignment conditions can monitor average net orientations and order parameters of individual bonds. By their simple geometrical dependence, RDCs...