Nathan Linial
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Explore the profile of Nathan Linial including associated specialties, affiliations and a list of published articles.
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20
Citations
369
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Recent Articles
1.
Mahlab-Aviv S, Linial N, Linial M
Front Mol Biosci
. 2022 Jan;
8:772852.
PMID: 34993232
A hallmark of cancer evolution is that the tumor may change its cell identity and improve its survival and fitness. Drastic change in microRNA (miRNA) composition and quantities accompany such...
2.
Brandes N, Linial N, Linial M
Sci Rep
. 2021 Jul;
11(1):14901.
PMID: 34290314
The characterization of germline genetic variation affecting cancer risk, known as cancer predisposition, is fundamental to preventive and personalized medicine. Studies of genetic cancer predisposition typically identify significant genomic regions...
3.
Rasnic R, Linial N, Linial M
Sci Rep
. 2020 Aug;
10(1):13462.
PMID: 32778766
It is estimated that up to 10% of cancer incidents are attributed to inherited genetic alterations. Despite extensive research, there are still gaps in our understanding of genetic predisposition to...
4.
Brandes N, Linial N, Linial M
Genome Biol
. 2020 Jul;
21(1):173.
PMID: 32665031
We introduce Proteome-Wide Association Study (PWAS), a new method for detecting gene-phenotype associations mediated by protein function alterations. PWAS aggregates the signal of all variants jointly affecting a protein-coding gene...
5.
Mahlab-Aviv S, Linial N, Linial M
PLoS Comput Biol
. 2019 Dec;
15(12):e1007204.
PMID: 31790387
Mature microRNAs (miRNAs) regulate most human genes through direct base-pairing with mRNAs. We investigate the underlying principles of miRNA regulation in living cells. To this end, we overexpressed miRNAs in...
6.
Brandes N, Linial N, Linial M
Nucleic Acids Res
. 2019 Jul;
47(13):6642-6655.
PMID: 31334812
Compiling the catalogue of genes actively involved in cancer is an ongoing endeavor, with profound implications to the understanding and treatment of the disease. An abundance of computational methods have...
7.
Rasnic R, Linial N, Linial M
Nucleic Acids Res
. 2017 Apr;
45(9):5048-5060.
PMID: 28379430
The primary function of microRNAs (miRNAs) is to maintain cell homeostasis. In cancerous tissues miRNAs' expression undergo drastic alterations. In this study, we use miRNA expression profiles from The Cancer...
8.
Rappoport N, Stern A, Linial N, Linial M
Bioinformatics
. 2014 Aug;
30(17):i624-30.
PMID: 25161256
Motivation: Modern protein sequencing techniques have led to the determination of >50 million protein sequences. ProtoNet is a clustering system that provides a continuous hierarchical agglomerative clustering tree for all...
9.
Rappoport N, Linial N, Linial M
Nat Biotechnol
. 2013 Apr;
31(4):290-2.
PMID: 23563419
No abstract available.
10.
Rappoport N, Karsenty S, Stern A, Linial N, Linial M
Nucleic Acids Res
. 2011 Nov;
40(Database issue):D313-20.
PMID: 22121228
ProtoNet 6.0 (http://www.protonet.cs.huji.ac.il) is a data structure of protein families that cover the protein sequence space. These families are generated through an unsupervised bottom-up clustering algorithm. This algorithm organizes large...