Michal Linial
Overview
Explore the profile of Michal Linial including associated specialties, affiliations and a list of published articles.
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146
Citations
2884
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Recent Articles
1.
Zucker R, Kelman G, Linial M
Nucleic Acids Res
. 2024 Nov;
53(D1):D1132-D1143.
PMID: 39565197
The Proteome-Wide Association Study (PWAS) is a protein-based genetic association approach designed to complement traditional variant-based methods like GWAS. PWAS operates in two stages: first, machine learning models predict the...
2.
Erster O, Shkedi O, Benedek G, Zilber E, Varkovitzky I, Shirazi R, et al.
PLoS One
. 2024 Nov;
19(11):e0314219.
PMID: 39541366
[This corrects the article DOI: 10.1371/journal.pone.0249149.].
3.
Kelman G, Zucker R, Brandes N, Linial M
Genome Res
. 2024 Oct;
34(10):1674-1686.
PMID: 39406500
PWAS (proteome-wide association study) is an innovative genetic association approach that complements widely used methods like GWAS (genome-wide association study). The PWAS approach involves consecutive phases. Initially, machine learning modeling...
4.
Zohar K, Linial M
Int J Mol Sci
. 2024 Jul;
25(14).
PMID: 39062793
PARK7, also known as DJ-1, plays a critical role in protecting cells by functioning as a sensitive oxidation sensor and modulator of antioxidants. DJ-1 acts to maintain mitochondrial function and...
5.
Passi G, Lieberman S, Zahdeh F, Murik O, Renbaum P, Beeri R, et al.
Brief Bioinform
. 2024 Jul;
25(4).
PMID: 39038933
Breast cancer (BC) is the most common malignancy affecting Western women today. It is estimated that as many as 10% of BC cases can be attributed to germline variants. However,...
6.
Zucker R, Kovalerchik M, Stern A, Kaufman H, Linial M
Front Genet
. 2024 Jun;
15:1409226.
PMID: 38919955
Hypothyroidism is a common endocrine disorder whose prevalence increases with age. The disease manifests itself when the thyroid gland fails to produce sufficient thyroid hormones. The disorder includes cases of...
7.
Ofer D, Linial M
J Biomed Inform
. 2024 May;
154:104650.
PMID: 38701887
Background: Distinguishing diseases into distinct subtypes is crucial for study and effective treatment strategies. The Open Targets Platform (OT) integrates biomedical, genetic, and biochemical datasets to empower disease ontologies, classifications,...
8.
Michael-Pitschaze T, Cohen N, Ofer D, Hoshen Y, Linial M
NAR Genom Bioinform
. 2024 Mar;
6(1):lqae021.
PMID: 38486884
Many advances in biomedicine can be attributed to identifying unusual proteins and genes. Many of these proteins' unique properties were discovered by manual inspection, which is becoming infeasible at the...
9.
Hochner H, Butterman R, Margaliot I, Friedlander Y, Linial M
Int J Obes (Lond)
. 2024 Mar;
48(7):954-963.
PMID: 38472354
Background/objectives: The effects of early life exposures on offspring life-course health are well established. This study assessed whether adding early socio-demographic and perinatal variables to a model based on polygenic...
10.
Reichert F, Zohar K, Lezmi E, Eliyahu T, Rotshenker S, Linial M, et al.
Biomolecules
. 2024 Jan;
14(1).
PMID: 38254713
Treatment of aging rats for 6 months with ladostigil (1 mg/kg/day) prevented a decline in recognition and spatial memory and suppressed the overexpression of gene-encoding pro-inflammatory cytokines, TNFα, IL1β, and...