Nathan Fishkin
Overview
Explore the profile of Nathan Fishkin including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
19
Citations
492
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0
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Recent Articles
1.
Jiang Z, Yang Z, Li F, Li Z, Fishkin N, Burgess K
Bioconjug Chem
. 2018 Aug;
29(9):2920-2926.
PMID: 30102524
This study was undertaken to target cell surface receptors other than the ones typically associated with breast cancer {estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor...
2.
Singh R, Setiady Y, Ponte J, Kovtun Y, Lai K, Hong E, et al.
Mol Cancer Ther
. 2016 May;
15(6):1311-20.
PMID: 27197308
A triglycyl peptide linker (CX) was designed for use in antibody -: drug conjugates (ADC), aiming to provide efficient release and lysosomal efflux of cytotoxic catabolites within targeted cancer cells....
3.
Ponte J, Sun X, Yoder N, Fishkin N, Laleau R, Coccia J, et al.
Bioconjug Chem
. 2016 May;
27(7):1588-98.
PMID: 27174129
Antibody-drug conjugates (ADCs) have become a widely investigated modality for cancer therapy, in part due to the clinical findings with ado-trastuzumab emtansine (Kadcyla). Ado-trastuzumab emtansine utilizes the Ab-SMCC-DM1 format, in...
4.
Widdison W, Ponte J, Coccia J, Lanieri L, Setiady Y, Dong L, et al.
Bioconjug Chem
. 2015 Sep;
26(11):2261-78.
PMID: 26355774
Antibody anilino maytansinoid conjugates (AaMCs) have been prepared in which a maytansinoid bearing an aniline group was linked through the aniline amine to a dipeptide, which in turn was covalently...
5.
Fishkin N
Mol Pharm
. 2015 Mar;
12(6):1745-51.
PMID: 25738231
Determining drug to antibody ratios (DAR) for antibody-drug conjugates (ADCs) in early research and development can be hampered by difficulties in accurate weighing of the effector payload and subsequent determination...
6.
Fishkin N, Maloney E, Chari R, Singh R
Chem Commun (Camb)
. 2011 Aug;
47(38):10752-4.
PMID: 21874179
A novel pathway for ex vivo maytansinoid release from thioether linked antibody maytansinoid conjugates (AMCs) upon incubation in human plasma has been identified. A thioether succinimide-linked AMC can undergo chemical...
7.
Wu Y, Zhou J, Fishkin N, Rittmann B, Sparrow J
J Am Chem Soc
. 2010 Dec;
133(4):849-57.
PMID: 21166406
Some forms of blinding macular disease are associated with excessive accumulation of bisretinoid lipofuscin in retinal pigment epithelial (RPE) cells of the eye. This material is refractory to lysosomal enzyme...
8.
Chen Y, Herrmann R, Fishkin N, Henklein P, Nakanishi K, Ernst O
Photochem Photobiol
. 2008 Feb;
84(4):831-8.
PMID: 18282180
G protein-coupled receptors (GPCRs) are involved in the control of virtually all aspects of our behavior and physiology. Activated receptors catalyze nucleotide exchange in heterotrimeric G proteins (composed of alpha.GDP,...
9.
Rogge B, Itagaki Y, Fishkin N, Levi E, Ruhl R, Yi S, et al.
J Nat Prod
. 2005 Oct;
68(10):1536-40.
PMID: 16252921
Insect cells convert vitamin A into a number of retinoids that are evolutionarily conserved with those of mammalian cells. However, insect cells also produce additional natural retinoids. Namely, two retinoic...
10.
Furuta T, Sakai M, Hayashi H, Asakawa T, Kataoka F, Fujii S, et al.
Chem Commun (Camb)
. 2005 Sep;
(36):4575-7.
PMID: 16158119
An artificial phospholipid, possessing saturated alkyl chains as a membrane anchor and protein recognition site as well as an Fe(III)-EDTA moiety as a protein cleavable polar head group, was designed...