Janet R Sparrow
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Explore the profile of Janet R Sparrow including associated specialties, affiliations and a list of published articles.
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198
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5890
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Recent Articles
1.
Sassone F, Estay-Ahumada C, Roux M, Ciocca D, Rossolillo P, Birling M, et al.
Sci Rep
. 2024 Dec;
14(1):30880.
PMID: 39730605
Mutations in the gene ABCA4 coding for photoreceptor-specific ATP-binding cassette subfamily A member 4, are responsible for Stargardts Disease type 1 (STGD1), the most common form of inherited macular degeneration....
2.
Li Y, Yang R, Li Y, Hsu C, Jenny L, Kong Y, et al.
JCI Insight
. 2024 Aug;
9(16).
PMID: 39171529
Patient-specific induced pluripotent stem cell-derived (iPSC-derived) cell lines allow for therapies to be tailored to individual patients, increasing therapeutic precision and efficiency. Bietti crystalline dystrophy (BCD) is a rare blinding...
3.
Zhao J, Kim H, Montenegro D, Dunaief J, Sparrow J
Front Ophthalmol (Lausanne)
. 2024 Jul;
3:1305864.
PMID: 38983013
Aim: Iron dysregulation in conjunction with other disease processes may exacerbate retinal degeneration. We employed models of iron overload and iron chelation to explore the interactions between iron-catalyzed oxidation and...
4.
Kunala K, Tang J, Bowles Johnson K, Huynh K, Parkins K, Kim H, et al.
Invest Ophthalmol Vis Sci
. 2024 May;
65(5):27.
PMID: 38758638
Purpose: To demonstrate the first near-infrared adaptive optics fluorescence lifetime imaging ophthalmoscopy (NIR-AOFLIO) measurements in vivo of the human retinal pigment epithelial (RPE) cellular mosaic and to visualize lifetime changes...
5.
Grubaugh C, Dhingra A, Prakash B, Montenegro D, Sparrow J, Daniele L, et al.
FASEB J
. 2024 Mar;
38(5):e23522.
PMID: 38445789
Lipid processing by the retinal pigment epithelium (RPE) is necessary to maintain retinal health and function. Dysregulation of retinal lipid homeostasis due to normal aging or age-related disease triggers lipid...
6.
Ramkumar S, Jastrzebska B, Montenegro D, Sparrow J, von Lintig J
J Biol Chem
. 2024 Feb;
300(3):105781.
PMID: 38395306
A delicate balance between photon absorption for vision and the protection of photoreceptors from light damage is pivotal for ocular health. This equilibrium is governed by the light-absorbing 11-cis-retinylidene chromophore...
7.
Grubaugh C, Dhingra A, Prakash B, Montenegro D, Sparrow J, Daniele L, et al.
bioRxiv
. 2023 Dec;
PMID: 38105975
Lipid processing by the retinal pigment epithelium (RPE) is necessary to maintain retinal health and function. Dysregulation of retinal lipid homeostasis due to normal aging or to age-related disease triggers...
8.
Parmann R, Tsang S, Sparrow J
Int J Mol Sci
. 2023 Aug;
24(15).
PMID: 37569703
The method of quantitative fundus autofluorescence (qAF) can be used to assess the levels of bisretinoids in retinal pigment epithelium (RPE) cells so as to aid the interpretation and management...
9.
Wang N, Liu P, Kong Y, Tseng Y, Jenny L, Nolan N, et al.
Cell Biosci
. 2023 Jun;
13(1):119.
PMID: 37381060
Background: Cones are essential for color recognition, high resolution, and central vision; therefore cone death causes blindness. Understanding the pathophysiology of each cell type in the retina is key to...
10.
Kim H, Zhao J, Walewski J, Sparrow J
J Biol Chem
. 2023 May;
299(6):104784.
PMID: 37146972
High dietary fat intake is associated with metabolic dysregulation, but little is known regarding the effects of a high fat diet (HFD) on photoreceptor cell functioning. We explored the intersection...