Natan J W Straathof
Overview
Explore the profile of Natan J W Straathof including associated specialties, affiliations and a list of published articles.
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13
Citations
420
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Recent Articles
1.
Sporer E, Deville C, Straathof N, Bruun L, Koster U, Jensen M, et al.
EJNMMI Radiopharm Chem
. 2024 Dec;
9(1):92.
PMID: 39738813
Background: Brachytherapy (BT) is routinely used in the treatment of various cancers. Current BT relies on the placement of large sources of radioactivity at the tumor site, requiring applicators that...
2.
Sap J, Meyer C, Ford J, Straathof N, Durr A, Lelos M, et al.
Nature
. 2022 Mar;
606(7912):102-108.
PMID: 35344982
The advent of total-body positron emission tomography (PET) has vastly broadened the range of research and clinical applications of this powerful molecular imaging technology. Such possibilities have accelerated progress in...
3.
Gendron T, Destro G, Straathof N, Sap J, Guibbal F, Vriamont C, et al.
EJNMMI Radiopharm Chem
. 2022 Mar;
7(1):5.
PMID: 35306596
Background: Flumazenil (FMZ) is a functionally silent imidazobenzodiazepine which binds to the benzodiazepine binding site of approximately 75% of the brain γ-aminobutyric acid-A receptors (GABARs). Positron Emission Tomography (PET) imaging...
4.
Straathof N, Magnus C, Zhuravlev F, Jensen A
Molecules
. 2021 Aug;
26(15).
PMID: 34361752
The field of targeted radionuclide therapy is rapidly growing, highlighting the need for wider radionuclide availability. Soft Lewis acid ions, such as radioisotopes of platinum, rhodium and palladium, are particularly...
5.
Sap J, Meyer C, Straathof N, Iwumene N, Am Ende C, Trabanco A, et al.
Chem Soc Rev
. 2021 Jun;
50(14):8214-8247.
PMID: 34075979
This review describes the recent advances made in difluoromethylation processes based on X-CFH bond formation where X is C(sp), C(sp), C(sp), O, N or S, a field of research that...
6.
Szpera R, Isenegger P, Ghosez M, Straathof N, Cookson R, Blakemore D, et al.
Org Lett
. 2020 Aug;
22(16):6573-6577.
PMID: 32806200
Herein, we report a highly effective protocol for the cross-coupling of (hetero)aryl bromides with fluorinated alcohols using the commercially available precatalyst BuBrettPhos Pd G3 and CsCO in toluene. This Pd-catalyzed...
7.
Sap J, Straathof N, Knauber T, Meyer C, Medebielle M, Buglioni L, et al.
J Am Chem Soc
. 2020 May;
142(20):9181-9187.
PMID: 32379965
Molecular editing such as insertion, deletion, and single atom exchange in highly functionalized compounds is an aspirational goal for all chemists. Here, we disclose a photoredox protocol for the replacement...
8.
Sap J, Wilson T, Kee C, Straathof N, Am Ende C, Mukherjee P, et al.
Chem Sci
. 2019 Apr;
10(11):3237-3241.
PMID: 30996907
Herein, we report the radiosynthesis of F-difluoromethylarenes the assembly of three components, a boron reagent, ethyl bromofluoroacetate, and cyclotron-produced non-carrier added [F]fluoride. The two key steps are a copper-catalysed cross-coupling...
9.
Straathof N, Cramer S, Hessel V, Noel T
Angew Chem Int Ed Engl
. 2016 Nov;
55(50):15549-15553.
PMID: 27862770
Styrenes represent a challenging class of substrates for current radical trifluoromethylation and hydrotrifluoromethylation methods due to a myriad of potential side reactions. Herein, we describe the development of mild, selective...
10.
Cambie D, Bottecchia C, Straathof N, Hessel V, Noel T
Chem Rev
. 2016 Mar;
116(17):10276-341.
PMID: 26935706
Continuous-flow photochemistry in microreactors receives a lot of attention from researchers in academia and industry as this technology provides reduced reaction times, higher selectivities, straightforward scalability, and the possibility to...