Synthesis of F-difluoromethylarenes Using Aryl Boronic Acids, Ethyl Bromofluoroacetate and [F]fluoride

Overview

Journal Chem Sci

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2019 Apr 19

PMID 30996907

Citations 9

Authors

Jeroen B I Sap

Thomas C Wilson

Choon Wee Kee

Natan J W Straathof

Christopher W Am Ende

Paramita Mukherjee

Lei Zhang

Christophe Genicot

Veronique Gouverneur

Affiliations

Soon will be listed here.

Abstract

Herein, we report the radiosynthesis of F-difluoromethylarenes the assembly of three components, a boron reagent, ethyl bromofluoroacetate, and cyclotron-produced non-carrier added [F]fluoride. The two key steps are a copper-catalysed cross-coupling reaction, and a Mn-mediated F-fluorodecarboxylation.

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