Jeroen B I Sap
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Explore the profile of Jeroen B I Sap including associated specialties, affiliations and a list of published articles.
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11
Citations
180
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Recent Articles
1.
Ford J, Ortalli S, Chen Z, Sap J, Tredwell M, Gouverneur V
Angew Chem Int Ed Engl
. 2024 Apr;
63(26):e202404945.
PMID: 38624193
Herein, we disclose that pyridinium salts derived from abundant (hetero)anilines represent a novel precursor class for nucleophilic aromatic substitution reactions with [F]fluoride. The value of this new F-fluorodeamination is demonstrated...
2.
Lin D, Lechermann L, Huestis M, Marik J, Sap J
Angew Chem Int Ed Engl
. 2023 Dec;
63(14):e202317136.
PMID: 38135665
This review discusses recent advances in light-driven radiochemistry for three key isotopes: fluorine-18, carbon-11, and zirconium-89, and their applications in positron emission tomography (PET). In the case of fluorine-18, the...
3.
Sap J, Meyer C, Ford J, Straathof N, Durr A, Lelos M, et al.
Nature
. 2022 Mar;
606(7912):102-108.
PMID: 35344982
The advent of total-body positron emission tomography (PET) has vastly broadened the range of research and clinical applications of this powerful molecular imaging technology. Such possibilities have accelerated progress in...
4.
Gendron T, Destro G, Straathof N, Sap J, Guibbal F, Vriamont C, et al.
EJNMMI Radiopharm Chem
. 2022 Mar;
7(1):5.
PMID: 35306596
Background: Flumazenil (FMZ) is a functionally silent imidazobenzodiazepine which binds to the benzodiazepine binding site of approximately 75% of the brain γ-aminobutyric acid-A receptors (GABARs). Positron Emission Tomography (PET) imaging...
5.
Hell S, Meyer C, Ortalli S, Sap J, Chen X, Gouverneur V
Chem Sci
. 2021 Oct;
12(36):12149-12155.
PMID: 34667580
A process for the direct hydrofluoromethylation of alkenes is reported for the first time. This straighforward silyl radical-mediated reaction utilises CHFI as a non-ozone depleting reagent, traditionally used in electrophilic,...
6.
Sap J, Meyer C, Straathof N, Iwumene N, Am Ende C, Trabanco A, et al.
Chem Soc Rev
. 2021 Jun;
50(14):8214-8247.
PMID: 34075979
This review describes the recent advances made in difluoromethylation processes based on X-CFH bond formation where X is C(sp), C(sp), C(sp), O, N or S, a field of research that...
7.
Josephson B, Fehl C, Isenegger P, Nadal S, Wright T, Poh A, et al.
Nature
. 2020 Sep;
585(7826):530-537.
PMID: 32968259
Post-translational modifications (PTMs) greatly expand the structures and functions of proteins in nature. Although synthetic protein functionalization strategies allow mimicry of PTMs, as well as formation of unnatural protein variants...
8.
Sap J, Straathof N, Knauber T, Meyer C, Medebielle M, Buglioni L, et al.
J Am Chem Soc
. 2020 May;
142(20):9181-9187.
PMID: 32379965
Molecular editing such as insertion, deletion, and single atom exchange in highly functionalized compounds is an aspirational goal for all chemists. Here, we disclose a photoredox protocol for the replacement...
9.
Hell S, Meyer C, Misale A, Sap J, Christensen K, Willis M, et al.
Angew Chem Int Ed Engl
. 2020 Apr;
59(28):11620-11626.
PMID: 32286720
Sulfonyl chlorides are inexpensive reactants extensively explored for functionalization, but never considered for radical hydrosulfonylation of alkenes. Herein, we report that tris(trimethylsilyl)silane is an ideal hydrogen atom donor enabling highly...
10.
Guibbal F, Isenegger P, Wilson T, Pacelli A, Mahaut D, Sap J, et al.
Nat Protoc
. 2020 Mar;
15(4):1525-1541.
PMID: 32111986
Positron emission tomography (PET) is a diagnostic nuclear imaging modality that relies on automated protocols to prepare agents labeled with a positron-emitting radionuclide (e.g., F). In recent years, new reactions...