Christopher W Am Ende
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Explore the profile of Christopher W Am Ende including associated specialties, affiliations and a list of published articles.
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57
Citations
968
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Recent Articles
1.
OBrien J, Conway L, Ramaraj P, Jadhav A, Jin J, Dutra J, et al.
Chem Sci
. 2024 Sep;
PMID: 39246352
Dialkyldiazirines have emerged as a photo-reactive group of choice for interactome mapping in live cell experiments. Upon irradiation, 'linear' dialkyldiazirines produce dialkylcarbenes which are susceptible to both intramolecular reactions and...
2.
Pettersson M, Johnson D, Humphrey J, Am Ende C, Butler T, Dorff P, et al.
J Med Chem
. 2024 Jun;
67(12):10248-10262.
PMID: 38848667
Herein, we describe the design and synthesis of γ-secretase modulator (GSM) clinical candidate PF-06648671 () for the treatment of Alzheimer's disease. A key component of the design involved a 2,5--tetrahydrofuran...
3.
Offensperger F, Tin G, Duran-Frigola M, Hahn E, Dobner S, Am Ende C, et al.
Science
. 2024 Apr;
384(6694):eadk5864.
PMID: 38662832
Chemical modulation of proteins enables a mechanistic understanding of biology and represents the foundation of most therapeutics. However, despite decades of research, 80% of the human proteome lacks functional ligands....
4.
Conole D, Cao F, Am Ende C, Xue L, Kantesaria S, Kang D, et al.
Angew Chem Int Ed Engl
. 2023 Oct;
62(47):e202311190.
PMID: 37779326
Deubiquitinases (DUBs) are a family of >100 proteases that hydrolyze isopeptide bonds linking ubiquitin to protein substrates, often leading to reduced substrate degradation through the ubiquitin proteasome system. Deregulation of...
5.
Tallon A, Xu Y, West G, Am Ende C, Fox J
J Am Chem Soc
. 2023 Jul;
145(29):16069-16080.
PMID: 37450839
Electrophilic small molecules that can reversibly modify proteins are of growing interest in drug discovery. However, the ability to study reversible covalent probes in live cells can be limited by...
6.
Mattheisen J, Limberakis C, Ruggeri R, Dowling M, Am Ende C, Ceraudo E, et al.
J Am Chem Soc
. 2023 Apr;
145(20):11173-11184.
PMID: 37116188
G protein-coupled receptors (GPCRs) modulate diverse cellular signaling pathways and are important drug targets. Despite the availability of high-resolution structures, the discovery of allosteric modulators remains challenging due to the...
7.
Carneiro S, Khasnavis S, Lee J, Butler T, Majmudar J, Am Ende C, et al.
Org Biomol Chem
. 2023 Jan;
21(7):1356-1372.
PMID: 36662157
Recent advances in the synthesis of sulfur(VI)-fluorides has enabled incredible growth in their application in biomolecular chemistry. This review aims to serve as a primer highlighting synthetic strategies toward a...
8.
Johnson Z, Ammirati M, Wasilko D, Chang J, Noell S, Foley T, et al.
Nat Struct Mol Biol
. 2022 Dec;
30(1):22-30.
PMID: 36522428
Glycerol-3-phosphate acyltransferase (GPAT)1 is a mitochondrial outer membrane protein that catalyzes the first step of de novo glycerolipid biosynthesis. Hepatic expression of GPAT1 is linked to liver fat accumulation and...
9.
Sap J, Meyer C, Ford J, Straathof N, Durr A, Lelos M, et al.
Nature
. 2022 Mar;
606(7912):102-108.
PMID: 35344982
The advent of total-body positron emission tomography (PET) has vastly broadened the range of research and clinical applications of this powerful molecular imaging technology. Such possibilities have accelerated progress in...
10.
Jemas A, Xie Y, Pigga J, Caplan J, Am Ende C, Fox J
J Am Chem Soc
. 2022 Jan;
144(4):1647-1662.
PMID: 35072462
Described is the spatiotemporally controlled labeling and patterning of biomolecules in live cells through the catalytic activation of bioorthogonal chemistry with light, referred to as "CABL". Here, an unreactive dihydrotetrazine...