Author: Natallia Makarava

1.

Reactive microglia partially envelop viable neurons in prion diseases

Makarava N, Safadi T, Bocharova O, Mychko O, Pandit N, Molesworth K, et al.

J Clin Invest . 2024 Oct; 134(23). PMID: 39361421

Microglia are recognized as the main cells in the central nervous system responsible for phagocytosis. The current study demonstrates that in prion disease, microglia effectively phagocytose prions or PrPSc during...

2.

Reactive astrocytes in prion diseases: Friend or foe?

Makarava N, Kushwaha R, Baskakov I

PLoS Pathog . 2024 Jun; 20(6):e1012286. PMID: 38900746

No abstract available.

3.

Multiple steps of prion strain adaptation to a new host

Bocharova O, Makarava N, Pandit N, Molesworth K, Baskakov I

Front Neurosci . 2024 Feb; 18:1329010. PMID: 38362022

The transmission of prions across species is a critical aspect of their dissemination among mammalian hosts, including humans. This process often necessitates strain adaptation. In this study, we sought to...

4.

Multiple steps of prion strain adaptation to a new host

Bocharova O, Makarava N, Pandit N, Molesworth K, Baskakov I

bioRxiv . 2023 Nov; PMID: 37961127

The transmission of prions across species is a critical aspect of their dissemination among mammalian hosts, including humans. This process often necessitates strain adaptation. In this study, we sought to...

5.

Region-Specific Homeostatic Identity of Astrocytes Is Essential for Defining Their Response to Pathological Insults

Makarava N, Mychko O, Molesworth K, Chang J, Henry R, Tsymbalyuk N, et al.

Cells . 2023 Sep; 12(17). PMID: 37681904

The transformation of astrocytes into reactive states constitutes a biological response of the central nervous system under a variety of pathological insults. Astrocytes display diverse homeostatic identities that are developmentally...

6.

Reactive astrocytes associated with prion disease impair the blood brain barrier

Kushwaha R, Li Y, Makarava N, Pandit N, Molesworth K, Birukov K, et al.

Neurobiol Dis . 2023 Aug; 185:106264. PMID: 37597815

Background: Impairment of the blood-brain barrier (BBB) is considered to be a common feature among neurodegenerative diseases, including Alzheimer's, Parkinson's and prion diseases. In prion disease, increased BBB permeability was...

7.

Reactive astrocytes associated with prion disease impair the blood brain barrier

Kushwaha R, Li Y, Makarava N, Pandit N, Molesworth K, Birukov K, et al.

bioRxiv . 2023 Mar; PMID: 36993690

Background: Impairment of the blood-brain barrier (BBB) is considered to be a common feature among neurodegenerative diseases, including Alzheimer's, Parkinson's and prion diseases. In prion disease, increased BBB permeability was...

8.

Deficiency in ST6GAL1, one of the two α2,6-sialyltransferases, has only a minor effect on the pathogenesis of prion disease

Makarava N, Katorcha E, Chang J, Lau J, Baskakov I

Front Mol Biosci . 2022 Dec; 9:1058602. PMID: 36452458

Prion diseases are a group of fatal neurodegenerative diseases caused by misfolding of the normal cellular form of the prion protein or PrP, into a disease-associated self-replicating state or PrP....

9.

Aβ plaques do not protect against HSV-1 infection in a mouse model of familial Alzheimer's disease, and HSV-1 does not induce Aβ pathology in a model of late onset Alzheimer's disease

Bocharova O, Fisher A, Pandit N, Molesworth K, Mychko O, Scott A, et al.

Brain Pathol . 2022 Sep; 33(1):e13116. PMID: 36064300

The possibility that the etiology of late onset Alzheimer's disease is linked to viral infections of the CNS has been actively debated in recent years. According to the antiviral protection...

10.

Role of sialylation of N-linked glycans in prion pathogenesis

Makarava N, Baskakov I

Cell Tissue Res . 2022 Jan; 392(1):201-214. PMID: 35088180

Mammalian prion or PrP is a proteinaceous infectious agent that consists of a misfolded, self-replicating state of the prion protein or PrP. PrP and PrP are posttranslationally modified with N-linked...