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Nataliya I Skrypnyk

Explore the profile of Nataliya I Skrypnyk including associated specialties, affiliations and a list of published articles. Areas
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Articles 11
Citations 449
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Recent Articles
1.
Tanaka S, Abe C, Abbott S, Zheng S, Yamaoka Y, Lipsey J, et al.
Proc Natl Acad Sci U S A . 2021 Mar; 118(12). PMID: 33737395
Acute kidney injury is highly prevalent and associated with high morbidity and mortality, and there are no approved drugs for its prevention and treatment. Vagus nerve stimulation (VNS) alleviates inflammatory...
2.
Brown C, Atwood D, Pokhrel D, Holditch S, Altmann C, Skrypnyk N, et al.
Cell Death Dis . 2021 Mar; 12(3):248. PMID: 33674554
Many surgical models are used to study kidney and other diseases in mice, yet the effects of the surgical procedure itself on the kidney and other tissues have not been...
3.
Skrypnyk N, Gist K, Okamura K, Montford J, You Z, Yang H, et al.
Kidney Int . 2020 Feb; 97(5):966-979. PMID: 32081304
Neutrophil gelatinase associated lipocalin (NGAL, Lcn2) is the most widely studied biomarker of acute kidney injury (AKI). Previous studies have demonstrated that NGAL is produced by the kidney and released...
4.
Chiusa M, Hu W, Liao H, Su Y, Borza C, de Caestecker M, et al.
J Am Soc Nephrol . 2019 Aug; 30(9):1605-1624. PMID: 31383731
Background: The discoidin domain receptor 1 (DDR1) is activated by collagens, upregulated in injured and fibrotic kidneys, and contributes to fibrosis by regulating extracellular matrix production, but how DDR1 controls...
5.
Fox B, Gil H, Kirkbride-Romeo L, Bagchi R, Wennersten S, Haefner K, et al.
Kidney Int . 2019 Feb; 95(3):590-610. PMID: 30709662
Acute kidney injury (AKI) is a systemic disease associated with widespread effects on distant organs, including the heart. Normal cardiac function is dependent on constant ATP generation, and the preferred...
6.
Skrypnyk N, Voziyan P, Yang H, de Caestecker C, Theberge M, Drouin M, et al.
Am J Physiol Renal Physiol . 2016 May; 311(2):F268-77. PMID: 27194713
Acute kidney injury (AKI) is a common and independent risk factor for death and chronic kidney disease (CKD). Despite promising preclinical data, there is no evidence that antioxidants reduce the...
7.
Skrypnyk N, Siskind L, Faubel S, de Caestecker M
Am J Physiol Renal Physiol . 2016 Mar; 310(10):F972-84. PMID: 26962107
The current lack of effective therapeutics for patients with acute kidney injury (AKI) represents an important and unmet medical need. Given the importance of the clinical problem, it is time...
8.
Skrypnyk N, Sanker S, Brilli Skvarca L, Novitskaya T, Woods C, Chiba T, et al.
Am J Physiol Renal Physiol . 2015 Dec; 310(8):F705-F716. PMID: 26661656
No therapies have been shown to accelerate recovery or prevent fibrosis after acute kidney injury (AKI). In part, this is because most therapeutic candidates have to be given at the...
9.
Chiba T, Skrypnyk N, Brilli Skvarca L, Penchev R, Zhang K, Rochon E, et al.
J Am Soc Nephrol . 2015 Jun; 27(2):495-508. PMID: 26109319
Retinoic acid (RA) has been used therapeutically to reduce injury and fibrosis in models of AKI, but little is known about the regulation of this pathway and what role it...
10.
Skrypnyk N, Harris R, de Caestecker M
J Vis Exp . 2013 Aug; (78). PMID: 23963468
Ischemia-reperfusion induced acute kidney injury (IR-AKI) is widely used as a model of AKI in mice, but results are often quite variable with high, often unreported mortality rates that may...