Charles L Edelstein
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Explore the profile of Charles L Edelstein including associated specialties, affiliations and a list of published articles.
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120
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11227
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Recent Articles
1.
Atwood D, He Z, Miyazaki M, Hailu F, Klawitter J, Edelstein C
Cell Signal
. 2024 Aug;
123:111351.
PMID: 39159908
In autosomal dominant polycystic kidney disease (ADPKD) there is cyst growth in the kidneys that leads to chronic kidney disease often requiring dialysis or kidney transplantation. There is enhanced aerobic...
2.
Chaudhary A, He Z, Atwood D, Miyazaki M, Oto O, Davidoff A, et al.
Am J Physiol Renal Physiol
. 2024 Apr;
326(6):F1004-F1015.
PMID: 38634129
Humans are predisposed to gout because they lack uricase that converts uric acid to allantoin. Rodents have uricase, resulting in low basal serum uric acid. A uricase inhibitor raises serum...
3.
Campbell R, Chen C, Edelstein C
Kidney Int Rep
. 2023 Nov;
8(11):2211-2225.
PMID: 38025228
Drug-induced nephrotoxicity accounts for up to 60% of cases of acute kidney injury (AKI) in hospitalized patients and is associated with increased morbidity and mortality in both adults and children....
4.
Oto O, Atwood D, Chaudhary A, He Z, Li A, Wempe M, et al.
Physiol Rep
. 2023 Aug;
11(17):e15776.
PMID: 37653564
Metformin (MET) has the potential to activate p-AMPK and block mTORC1-induced proliferation of tubular cells in PKD kidneys. The aim of this study was to determine the effects of MET...
5.
Stenson E, Edelstein C, You Z, Miyazaki-Anzai S, Thurman J, Dixon B, et al.
Kidney360
. 2023 Feb;
4(3):326-332.
PMID: 36758197
No abstract available.
6.
Oto O, Edelstein C
Nephron
. 2022 Jul;
148(4):215-223.
PMID: 35896062
Heart disease is one of the leading causes of death in autosomal dominant polycystic kidney disease (ADPKD) patients. Left ventricular hypertrophy (LVH) is an early and severe complication in ADPKD...
7.
Li A, Ambruso S, Oto O, Barry M, Edelstein C
BMC Nephrol
. 2022 Jul;
23(1):264.
PMID: 35870899
Background: Glomerular endotheliosis is the pathognomonic glomerular lesion in pre-eclampsia that has also been described in those taking tyrosine kinase inhibitors for cancer treatment. Ibrutinib is a Bruton's tyrosine kinase...
8.
Brown C, Atwood D, Pokhrel D, Holditch S, Altmann C, Skrypnyk N, et al.
Cell Death Dis
. 2021 Mar;
12(3):248.
PMID: 33674554
Many surgical models are used to study kidney and other diseases in mice, yet the effects of the surgical procedure itself on the kidney and other tissues have not been...
9.
Klionsky D, Abdel-Aziz A, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, et al.
Autophagy
. 2021 Feb;
17(1):1-382.
PMID: 33634751
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our...
10.
Atwood D, Brown C, Holditch S, Pokhrel D, Thorburn A, Hopp K, et al.
Cell Signal
. 2020 Sep;
75:109760.
PMID: 32866627
Autosomal dominant polycystic kidney disease (ADPKD) is a common inherited disorder characterized by kidney cyst growth often resulting in end-stage renal disease. There is growing attention on understanding the role...