Nancy E Kohl
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Explore the profile of Nancy E Kohl including associated specialties, affiliations and a list of published articles.
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Articles
34
Citations
1356
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Recent Articles
1.
Lin J, Horan J, Tangpeerachaikul A, Swalduz A, Valdivia A, Johnson M, et al.
Cancer Discov
. 2024 Sep;
14(12):2367-2386.
PMID: 39269178
Three generations of tyrosine kinase inhibitors (TKI) have been approved for anaplastic lymphoma kinase (ALK) fusion-positive non-small cell lung cancer. However, none address the combined need for broad resistance coverage,...
2.
Drilon A, Horan J, Tangpeerachaikul A, Besse B, Ou S, Gadgeel S, et al.
Cancer Discov
. 2022 Dec;
13(3):598-615.
PMID: 36511802
The combined preclinical features of NVL-520 that include potent targeting of ROS1 and diverse ROS1 resistance mutations, high selectivity for ROS1 G2032R over TRK, and brain penetration mark the development...
3.
Czako B, Sun Y, McAfoos T, Cross J, Leonard P, Burke J, et al.
J Med Chem
. 2021 Oct;
64(20):15141-15169.
PMID: 34643390
Src homology 2 (SH2) domain-containing phosphatase 2 (SHP2) plays a role in receptor tyrosine kinase (RTK), neurofibromin-1 (NF-1), and Kirsten rat sarcoma virus (KRAS) mutant-driven cancers, as well as in...
4.
Sun Y, Meyers B, Czako B, Leonard P, Mseeh F, Harris A, et al.
Cancer Res
. 2020 Sep;
80(21):4840-4853.
PMID: 32928921
Src homology 2 domain-containing phosphatase (SHP2) is a phosphatase that mediates signaling downstream of multiple receptor tyrosine kinases (RTK) and is required for full activation of the MAPK pathway. SHP2...
5.
Kim R, Sarker D, Meyer T, Yau T, Macarulla T, Park J, et al.
Cancer Discov
. 2019 Oct;
9(12):1696-1707.
PMID: 31575541
Outcomes for patients with advanced hepatocellular carcinoma (HCC) remain poor despite recent progress in drug development. Emerging data implicate FGF19 as a potential HCC driver, suggesting its receptor, FGFR4, as...
6.
Reardon D, Gokhale P, Klein S, Ligon K, Rodig S, Ramkissoon S, et al.
Cancer Immunol Res
. 2015 Nov;
4(2):124-35.
PMID: 26546453
Inhibition of immune checkpoints, including cytotoxic T-lymphocyte antigen-4 (CTLA-4), programmed death-1 (PD-1), and its ligand PD-L1, has demonstrated exciting and durable remissions across a spectrum of malignancies. Combinatorial regimens blocking...
7.
Pelish H, Liau B, Nitulescu I, Tangpeerachaikul A, Poss Z, Da Silva D, et al.
Nature
. 2015 Sep;
526(7572):273-276.
PMID: 26416749
Super-enhancers (SEs), which are composed of large clusters of enhancers densely loaded with the Mediator complex, transcription factors and chromatin regulators, drive high expression of genes implicated in cell identity...
8.
McCall K, Cheng S, Huang Y, Kohl N, Tupper T, Van Den Abbeele A, et al.
Transl Oncol
. 2015 Jun;
8(3):147-53.
PMID: 26055171
Preclinical xenograft models have contributed to advancing our understanding of the molecular basis of prostate cancer and to the development of targeted therapy. However, traditional preclinical in vivo techniques using...
9.
Nonami A, Sattler M, Weisberg E, Liu Q, Zhang J, Patricelli M, et al.
Blood
. 2015 Apr;
125(20):3133-43.
PMID: 25833960
Oncogenic forms of NRAS are frequently associated with hematologic malignancies and other cancers, making them important therapeutic targets. Inhibition of individual downstream effector molecules (eg, RAF kinase) have been complicated...
10.
Hagel M, Miduturu C, Sheets M, Rubin N, Weng W, Stransky N, et al.
Cancer Discov
. 2015 Mar;
5(4):424-37.
PMID: 25776529
Unlabelled: Aberrant signaling through the fibroblast growth factor 19 (FGF19)/fibroblast growth factor receptor 4 (FGFR 4) signaling complex has been shown to cause hepatocellular carcinoma (HCC) in mice and has...