Nancy D Pomarici
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Explore the profile of Nancy D Pomarici including associated specialties, affiliations and a list of published articles.
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10
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82
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Recent Articles
1.
Hoerschinger V, Waibl F, Pomarici N, Loeffler J, Deane C, Georges G, et al.
J Chem Inf Model
. 2023 Nov;
63(22):6964-6971.
PMID: 37934909
The electrostatic properties of proteins arise from the number and distribution of polar and charged residues. Electrostatic interactions in proteins play a critical role in numerous processes such as molecular...
2.
Fernandez-Quintero M, Pomarici N, Fischer A, Hoerschinger V, Kroell K, Riccabona J, et al.
Antibodies (Basel)
. 2023 Oct;
12(4).
PMID: 37873864
Antibodies and other new antibody-like formats have emerged as one of the most rapidly growing classes of biotherapeutic proteins. Understanding the structural features that drive antibody function and, consequently, their...
3.
Pomarici N, Cacciato R, Kokot J, Fernandez-Quintero M, Liedl K
Biomolecules
. 2023 May;
13(5).
PMID: 37238671
The adaptive immune system arose around 500 million years ago in jawed fish, and, since then, it has mediated the immune defense against pathogens in all vertebrates. Antibodies play a...
4.
Pomarici N, Waibl F, Quoika P, Bujotzek A, Georges G, Fernandez-Quintero M, et al.
J Comput Aided Mol Des
. 2023 Mar;
37(4):201-215.
PMID: 36918473
Therapeutic antibodies should not only recognize antigens specifically, but also need to be free from developability issues, such as poor stability. Thus, the mechanistic understanding and characterization of stability are...
5.
Pomarici N, Fernandez-Quintero M, Quoika P, Waibl F, Bujotzek A, Georges G, et al.
Protein Eng Des Sel
. 2022 Dec;
35.
PMID: 36468666
A new format of therapeutic proteins is bispecific antibodies, in which two different heavy chains heterodimerize to obtain two different binding sites. Therefore, it is crucial to understand and optimize...
6.
Fernandez-Quintero M, Quoika P, Wedl F, Seidler C, Kroell K, Loeffler J, et al.
Front Mol Biosci
. 2022 Mar;
9:864654.
PMID: 35242816
[This corrects the article DOI: 10.3389/fmolb.2022.812750.].
7.
Fernandez-Quintero M, Quoika P, Wedl F, Seidler C, Kroell K, Loeffler J, et al.
Front Mol Biosci
. 2022 Feb;
9:812750.
PMID: 35155578
As the current biotherapeutic market is dominated by antibodies, the design of different antibody formats, like bispecific antibodies and other new formats, represent a key component in advancing antibody therapy....
8.
Fernandez-Quintero M, Pomarici N, Math B, Kroell K, Waibl F, Bujotzek A, et al.
Commun Biol
. 2020 Oct;
3(1):589.
PMID: 33082531
In the last decades, antibodies have emerged as one of the most important and successful classes of biopharmaceuticals. The highest variability and diversity of an antibody is concentrated on six...
9.
Fernandez-Quintero M, Pomarici N, Loeffler J, Seidler C, Liedl K
Front Immunol
. 2020 Aug;
11:1440.
PMID: 32733478
T-cell receptors are an important part in the adaptive immune system as they are responsible for detecting foreign proteins presented by the major histocompatibility complex (MHC). The affinity is predominantly...
10.
Fernandez-Quintero M, Heiss M, Pomarici N, Math B, Liedl K
MAbs
. 2020 Apr;
12(1):1744328.
PMID: 32264741
In the past decade, the relevance of antibodies as therapeutics has increased substantially. Therefore, structural and functional characterization, in particular of the complementarity-determining regions (CDRs), is crucial to the design...