Johannes R Loeffler
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Explore the profile of Johannes R Loeffler including associated specialties, affiliations and a list of published articles.
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31
Citations
248
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Recent Articles
1.
Reyes R, Raghavan S, Hurlburt N, Introini V, Bol S, Kana I, et al.
Nature
. 2024 Nov;
636(8041):182-189.
PMID: 39567685
Malaria pathology is driven by the accumulation of Plasmodium falciparum-infected erythrocytes in microvessels. This process is mediated by the polymorphic erythrocyte membrane protein 1 (PfEMP1) adhesion proteins of the parasite....
2.
Erasmus M, Spector L, Ferrara F, DiNiro R, Pohl T, Perea-Schmittle K, et al.
Nat Biotechnol
. 2024 Nov;
42(11):1637-1642.
PMID: 39496931
No abstract available.
3.
Bruciaferri N, Eberhardt J, Llanos M, Loeffler J, Holcomb M, Fernandez-Quintero M, et al.
J Chem Inf Model
. 2024 Oct;
64(21):8227-8235.
PMID: 39436011
Cosolvent molecular dynamics (MDs) are an increasingly popular form of simulations where small molecule cosolvents are added to water-solvated protein systems. These simulations can perform diverse target characterization tasks, including...
4.
Fernandez-Quintero M, Guarnera E, Musil D, Pekar L, Sellmann C, Freire F, et al.
Protein Sci
. 2024 Oct;
33(11):e5176.
PMID: 39422475
The humanization of camelid-derived variable domain heavy chain antibodies (VHHs) poses challenges including immunogenicity, stability, and potential reduction of affinity. Critical to this process are complementarity-determining regions (CDRs), Vernier and...
5.
Riccabona J, Spoendlin F, Fischer A, Loeffler J, Quoika P, Jenkins T, et al.
Structure
. 2024 Sep;
32(11):2147-2159.e2.
PMID: 39332396
Recent breakthroughs in protein structure prediction have enhanced the precision and speed at which protein configurations can be determined. Additionally, molecular dynamics (MD) simulations serve as a crucial tool for...
6.
Fischer A, Tichy A, Kokot J, Hoerschinger V, Wild R, Riccabona J, et al.
J Chem Theory Comput
. 2024 Feb;
20(5):2321-2333.
PMID: 38373307
Protein folding is a fascinating, not fully understood phenomenon in biology. Molecular dynamics (MD) simulations are an invaluable tool to study conformational changes in atomistic detail, including folding and unfolding...
7.
Reyes R, Raghavan S, Hurlburt N, Introini V, Kana I, Jensen R, et al.
bioRxiv
. 2024 Feb;
PMID: 38328068
pathology is driven by the accumulation of parasite-infected erythrocytes in microvessels. This process is mediated by the parasite's polymorphic erythrocyte membrane protein 1 (PfEMP1) adhesion proteins. A subset of PfEMP1...
8.
Hoerschinger V, Waibl F, Pomarici N, Loeffler J, Deane C, Georges G, et al.
J Chem Inf Model
. 2023 Nov;
63(22):6964-6971.
PMID: 37934909
The electrostatic properties of proteins arise from the number and distribution of polar and charged residues. Electrostatic interactions in proteins play a critical role in numerous processes such as molecular...
9.
Tulika T, Pedersen R, Rimbault C, Ahmadi S, Rivera-de-Torre E, Fernandez-Quintero M, et al.
Protein Sci
. 2023 Oct;
32(12):e4821.
PMID: 37897425
Recycling IgG antibodies bind to their target antigen at physiological pH in the blood stream and release them upon endocytosis when pH levels drop, allowing the IgG antibodies to be...
10.
Fernandez-Quintero M, Pomarici N, Fischer A, Hoerschinger V, Kroell K, Riccabona J, et al.
Antibodies (Basel)
. 2023 Oct;
12(4).
PMID: 37873864
Antibodies and other new antibody-like formats have emerged as one of the most rapidly growing classes of biotherapeutic proteins. Understanding the structural features that drive antibody function and, consequently, their...