Nan M Laird
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Explore the profile of Nan M Laird including associated specialties, affiliations and a list of published articles.
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80
Citations
3086
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Recent Articles
1.
Hayden L, Hobbs B, Busch R, Cho M, Liu M, Lopes-Ramos C, et al.
Respir Res
. 2023 Feb;
24(1):38.
PMID: 36726148
Background: The association between genetic variants on the X chromosome to risk of COPD has not been fully explored. We hypothesize that the X chromosome harbors variants important in determining...
2.
Hahn G, Wu C, Lee S, Lutz S, Khurana S, Baden L, et al.
Genet Epidemiol
. 2021 Jun;
45(7):685-693.
PMID: 34159627
SARS-CoV-2 mortality has been extensively studied in relation to host susceptibility. How sequence variations in the SARS-CoV-2 genome affect pathogenicity is poorly understood. Starting in October 2020, using the methodology...
3.
Hecker J, Townes F, Kachroo P, Laurie C, Lasky-Su J, Ziniti J, et al.
Bioinformatics
. 2020 Dec;
36(22-23):5432-5438.
PMID: 33367522
Motivation: Analysis of rare variants in family-based studies remains a challenge. Transmission-based approaches provide robustness against population stratification, but the evaluation of the significance of test statistics based on asymptotic...
4.
Sato Y, Gosho M, Nagashima K, Takahashi S, Ware J, Laird N
N Engl J Med
. 2017 Mar;
376(11):1086-1087.
PMID: 28296608
No abstract available.
5.
Qiao D, Lange C, Laird N, Won S, Hersh C, Morrow J, et al.
Genet Epidemiol
. 2017 Feb;
41(4):309-319.
PMID: 28191685
Whole-exome sequencing using family data has identified rare coding variants in Mendelian diseases or complex diseases with Mendelian subtypes, using filters based on variant novelty, functionality, and segregation with the...
6.
Boueiz A, Lutz S, Cho M, Hersh C, Bowler R, Washko G, et al.
Am J Respir Crit Care Med
. 2016 Sep;
195(6):757-771.
PMID: 27669027
Rationale: Emphysema has considerable variability in the severity and distribution of parenchymal destruction throughout the lungs. Upper lobe-predominant emphysema has emerged as an important predictor of response to lung volume...
7.
Hobbs B, Parker M, Chen H, Lao T, Hardin M, Qiao D, et al.
Am J Respir Crit Care Med
. 2016 Jan;
194(1):48-57.
PMID: 26771213
Rationale: Chronic obstructive pulmonary disease (COPD) susceptibility is in part related to genetic variants. Most genetic studies have been focused on genome-wide common variants without a specific focus on coding...
8.
Lutz S, Cho M, Young K, Hersh C, Castaldi P, McDonald M, et al.
BMC Genet
. 2015 Dec;
16:138.
PMID: 26634245
Background: Pulmonary function decline is a major contributor to morbidity and mortality among smokers. Post bronchodilator FEV1 and FEV1/FVC ratio are considered the standard assessment of airflow obstruction. We performed...
9.
Zhou J, Cho M, Lange C, Lutz S, Silverman E, Laird N
Hum Hered
. 2015 Jun;
79(2):93-104.
PMID: 26111731
Many correlated disease variables are analyzed jointly in genetic studies in the hope of increasing power to detect causal genetic variants. One approach involves assessing the relationship between each phenotype...
10.
Cho M, Castaldi P, Hersh C, Hobbs B, Barr R, Tal-Singer R, et al.
Am J Respir Crit Care Med
. 2015 Jun;
192(5):559-69.
PMID: 26030696
Rationale: Chronic obstructive pulmonary disease (COPD) is defined by the presence of airflow limitation on spirometry, yet subjects with COPD can have marked differences in computed tomography imaging. These differences...