Nallathamby Devasahayam
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Explore the profile of Nallathamby Devasahayam including associated specialties, affiliations and a list of published articles.
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51
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969
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Recent Articles
11.
Matsumoto S, Kishimoto S, Saito K, Takakusagi Y, Munasinghe J, Devasahayam N, et al.
Cancer Res
. 2018 May;
78(14):3783-3792.
PMID: 29792309
Pancreatic ductal adenocarcinoma (PDAC) is characterized by hypoxic niches that lead to treatment resistance. Therefore, studies of tumor oxygenation and metabolic profiling should contribute to improved treatment strategies. Here, we...
12.
Enomoto A, Qian C, Devasahayam N, Kishimoto S, Oshima N, Blackman B, et al.
Magn Reson Med
. 2018 Apr;
80(5):2288-2298.
PMID: 29603378
Purpose: To develop an implantable wireless coil with parametric amplification capabilities for time-domain electron paramagnetic resonance (EPR) spectroscopy operating at 300 MHz. Methods: The wireless coil and lithium phthalocyanine (LiPc),...
13.
Matsumoto K, Kishimoto S, Devasahayam N, Chandramouli G, Ogawa Y, Matsumoto S, et al.
Magn Reson Med
. 2018 Mar;
80(5):2275-2287.
PMID: 29582458
Purpose: Spin-lattice relaxation rate (R )-based time-domain EPR oximetry is reported for in vivo applications using a paramagnetic probe, a trityl-based Oxo71. Methods: The R dependence of the trityl probe...
14.
Kishimoto S, Matsumoto K, Saito K, Enomoto A, Matsumoto S, Mitchell J, et al.
Antioxid Redox Signal
. 2017 Nov;
28(15):1378-1393.
PMID: 29130334
Significance: Electron paramagnetic resonance imaging (EPRI) is capable of generating images of tissue oxygenation using exogenous paramagnetic probes such as trityl radicals or nitroxyl radicals. The spatial distribution of the...
15.
Yasui H, Kawai T, Matsumoto S, Saito K, Devasahayam N, Mitchell J, et al.
Free Radic Res
. 2017 Oct;
51(9-10):861-871.
PMID: 29076398
Hypoxia is considered one of the microenvironmental factors associated with the malignant nature of glioblastoma. Thus, evaluating intratumoural distribution of hypoxia would be useful for therapeutic planning as well as...
16.
Chou C, Chandramouli G, Shin T, Devasahayam N, McMillan A, Babadi B, et al.
Magn Reson Imaging
. 2016 Dec;
37:90-99.
PMID: 27989911
Purpose: Electron paramagnetic resonance (EPR) imaging has evolved as a promising tool to provide non-invasive assessment of tissue oxygenation levels. Due to the extremely short T relaxation time of electrons,...
17.
Saito K, Matsumoto S, Takakusagi Y, Matsuo M, Morris H, Lizak M, et al.
Clin Cancer Res
. 2015 Feb;
21(22):5073-81.
PMID: 25673698
Purpose: X-ray irradiation of tumors causes diverse effects on the tumor microenvironment, including metabolism. Recent developments of hyperpolarized (13)C-MRI enabled detecting metabolic changes in tumors using a tracer [1-(13)C]pyruvate, which...
18.
Takakusagi Y, Matsumoto S, Saito K, Matsuo M, Kishimoto S, Wojtkowiak J, et al.
PLoS One
. 2014 Sep;
9(9):e107995.
PMID: 25254649
Background: TH-302 is a hypoxia-activated prodrug (HAP) of bromo isophosphoramide mustard that is selectively activated within hypoxic regions in solid tumors. Our recent study showed that intravenously administered bolus pyruvate...
19.
Jang H, Matsumoto S, Devasahayam N, Subramanian S, Zhuo J, Krishna M, et al.
Magn Reson Med
. 2014 May;
73(4):1692-701.
PMID: 24803382
Purpose: Electron paramagnetic resonance imaging has surfaced as a promising noninvasive imaging modality that is capable of imaging tissue oxygenation. Due to extremely short spin-spin relaxation times, electron paramagnetic resonance...
20.
Matsumoto S, Saito K, Takakusagi Y, Matsuo M, Munasinghe J, Morris H, et al.
Antioxid Redox Signal
. 2014 Mar;
21(8):1145-55.
PMID: 24597714
Aims: The tumor microenvironment is characterized by a highly reducing redox status, a low pH, and hypoxia. Anti-angiogenic therapies for solid tumors frequently function in two steps: the transient normalization...